Targeting signaling pathways in prostate cancer: mechanisms and clinical trials

Y He, W Xu, YT Xiao, H Huang, D Gu… - Signal transduction and …, 2022 - nature.com
Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

Exosomes in angiogenesis and anti-angiogenic therapy in cancers

W Olejarz, G Kubiak-Tomaszewska… - International Journal of …, 2020 - mdpi.com
Angiogenesis is the process through which new blood vessels are formed from pre-existing
ones. Exosomes are involved in angiogenesis in cancer progression by transporting …

Role of VEGFs/VEGFR-1 signaling and its inhibition in modulating tumor invasion: experimental evidence in different metastatic cancer models

C Ceci, MG Atzori, PM Lacal, G Graziani - International journal of …, 2020 - mdpi.com
The vascular endothelial growth factor (VEGF) family members, VEGF-A, placenta growth
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …

Angiogenesis and anti-angiogenic treatment in prostate cancer: mechanisms of action and molecular targets

E Ioannidou, M Moschetta, S Shah, JS Parker… - International journal of …, 2021 - mdpi.com
Prostate cancer (PC) is the most common cancer in men and the second leading cause of
cancer-related death worldwide. Many therapeutic advances over the last two decades have …

Targeted therapy for cancers: from ongoing clinical trials to FDA-approved drugs

HY Choi, JE Chang - International Journal of Molecular Sciences, 2023 - mdpi.com
The development of targeted therapies has revolutionized cancer treatment, offering
improved efficacy with reduced side effects compared with traditional chemotherapy. This …

Neovascular macular degeneration: a review of etiology, risk factors, and recent advances in research and therapy

A Pugazhendhi, M Hubbell, P Jairam… - International Journal of …, 2021 - mdpi.com
Neovascular age-related macular degeneration (exudative or wet AMD) is a prevalent,
progressive retinal degenerative macular disease that is characterized by …

Tumor microenvironment in prostate cancer: toward identification of novel molecular biomarkers for diagnosis, prognosis, and therapy development

HF Bahmad, M Jalloul, J Azar, MM Moubarak… - Frontiers in …, 2021 - frontiersin.org
Prostate cancer (PCa) is by far the most commonly diagnosed cancer in men worldwide.
Despite sensitivity to androgen deprivation, patients with advanced disease eventually …

Oncolytic virus encoding a master pro-inflammatory cytokine interleukin 12 in cancer immunotherapy

HM Nguyen, K Guz-Montgomery, D Saha - Cells, 2020 - mdpi.com
Oncolytic viruses (OVs) are genetically modified or naturally occurring viruses, which
preferentially replicate in and kill cancer cells while sparing healthy cells, and induce anti …

The FGF/FGFR system in the physiopathology of the prostate gland

A Giacomini, E Grillo, S Rezzola… - Physiological …, 2021 - journals.physiology.org
Fibroblast growth factors (FGFs) are a family of proteins possessing paracrine, autocrine, or
endocrine functions in a variety of biological processes, including embryonic development …

Role of bFGF in acquired resistance upon anti-VEGF therapy in cancer

FT Zahra, MS Sajib, CM Mikelis - Cancers, 2021 - mdpi.com
Simple Summary Anti-angiogenic therapies targeting the vascular endothelial growth factor
(VEGF) signaling are established in the arsenal of cancer treatments. Despite the …