Targeting signaling pathways in prostate cancer: mechanisms and clinical trials
Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …
genomic landscapes and biological functions, the treatment of PCa continues to improve …
Exosomes in angiogenesis and anti-angiogenic therapy in cancers
W Olejarz, G Kubiak-Tomaszewska… - International Journal of …, 2020 - mdpi.com
Angiogenesis is the process through which new blood vessels are formed from pre-existing
ones. Exosomes are involved in angiogenesis in cancer progression by transporting …
ones. Exosomes are involved in angiogenesis in cancer progression by transporting …
Role of VEGFs/VEGFR-1 signaling and its inhibition in modulating tumor invasion: experimental evidence in different metastatic cancer models
C Ceci, MG Atzori, PM Lacal, G Graziani - International journal of …, 2020 - mdpi.com
The vascular endothelial growth factor (VEGF) family members, VEGF-A, placenta growth
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …
Angiogenesis and anti-angiogenic treatment in prostate cancer: mechanisms of action and molecular targets
E Ioannidou, M Moschetta, S Shah, JS Parker… - International journal of …, 2021 - mdpi.com
Prostate cancer (PC) is the most common cancer in men and the second leading cause of
cancer-related death worldwide. Many therapeutic advances over the last two decades have …
cancer-related death worldwide. Many therapeutic advances over the last two decades have …
Targeted therapy for cancers: from ongoing clinical trials to FDA-approved drugs
HY Choi, JE Chang - International Journal of Molecular Sciences, 2023 - mdpi.com
The development of targeted therapies has revolutionized cancer treatment, offering
improved efficacy with reduced side effects compared with traditional chemotherapy. This …
improved efficacy with reduced side effects compared with traditional chemotherapy. This …
Neovascular macular degeneration: a review of etiology, risk factors, and recent advances in research and therapy
A Pugazhendhi, M Hubbell, P Jairam… - International Journal of …, 2021 - mdpi.com
Neovascular age-related macular degeneration (exudative or wet AMD) is a prevalent,
progressive retinal degenerative macular disease that is characterized by …
progressive retinal degenerative macular disease that is characterized by …
Tumor microenvironment in prostate cancer: toward identification of novel molecular biomarkers for diagnosis, prognosis, and therapy development
Prostate cancer (PCa) is by far the most commonly diagnosed cancer in men worldwide.
Despite sensitivity to androgen deprivation, patients with advanced disease eventually …
Despite sensitivity to androgen deprivation, patients with advanced disease eventually …
Oncolytic virus encoding a master pro-inflammatory cytokine interleukin 12 in cancer immunotherapy
Oncolytic viruses (OVs) are genetically modified or naturally occurring viruses, which
preferentially replicate in and kill cancer cells while sparing healthy cells, and induce anti …
preferentially replicate in and kill cancer cells while sparing healthy cells, and induce anti …
The FGF/FGFR system in the physiopathology of the prostate gland
Fibroblast growth factors (FGFs) are a family of proteins possessing paracrine, autocrine, or
endocrine functions in a variety of biological processes, including embryonic development …
endocrine functions in a variety of biological processes, including embryonic development …
Role of bFGF in acquired resistance upon anti-VEGF therapy in cancer
FT Zahra, MS Sajib, CM Mikelis - Cancers, 2021 - mdpi.com
Simple Summary Anti-angiogenic therapies targeting the vascular endothelial growth factor
(VEGF) signaling are established in the arsenal of cancer treatments. Despite the …
(VEGF) signaling are established in the arsenal of cancer treatments. Despite the …