Cerebrospinal fluid: a target of some fungi and an overview

D Corrêa-Moreira, R Castro, GL da Costa… - Memórias do Instituto …, 2023 - SciELO Brasil
Meningitis is a potentially life-threatening infection characterised by the inflammation of the
leptomeningeal membranes. The estimated annual prevalence of 8.7 million cases globally …

Cryptococcal immune reconstitution inflammatory syndrome: from clinical studies to animal experiments

ZW Shi, Y Chen, KM Ogoke, AB Strickland, M Shi - Microorganisms, 2022 - mdpi.com
Cryptococcus neoformans is an encapsulated pathogenic fungus that initially infects the
lung but can migrate to the central nervous system (CNS), resulting in meningoencephalitis …

Alternatively activated lung alveolar and interstitial macrophages promote fungal growth

AB Strickland, Y Chen, D Sun, M Shi - Iscience, 2023 - cell.com
How lung macrophages, especially interstitial macrophages (IMs), respond to invading
pathogens remains elusive. Here, we show that mice exhibited a rapid and substantial …

New silicate-substituted hydroxyapatite materials doped with silver ions as potential antifungal agents

A Piecuch, S Targońska, J Rewak-Sorczyńska… - BMC microbiology, 2023 - Springer
Abstract Background Hydroxyapatites (HAp) are widely used as medical preparations for eg,
bone replacement or teeth implants. Incorporation of various substrates into HAp structures …

Preclinical Models for Cryptococcosis of the CNS and Their Characterization Using In Vivo Imaging Techniques

L Roosen, D Maes, L Musetta, U Himmelreich - Journal of Fungi, 2024 - mdpi.com
Infections caused by Cryptococcus neoformans and Cryptococcus gattii remain a challenge
to our healthcare systems as they are still difficult to treat. In order to improve treatment …

Clinical and epidemiological characteristics of neurocryptococcosis associated with HIV in northeastern Brazil

EP Oliveira, BR de Sousa, JF de Freitas, RP Neves… - Viruses, 2023 - mdpi.com
Cryptococcal meningitis is a serious infection of the central nervous system that is
predominant in developing countries, caused by fungi of the genus Cryptococcus, and which …

Innate Pulmonary Phagocytes and Their Interactions with Pathogenic Cryptococcus Species

BN Conn, KL Wozniak - Journal of Fungi, 2023 - mdpi.com
Cryptococcus neoformans is an opportunistic fungal pathogen that causes over 180,000
annual deaths in HIV/AIDS patients. Innate phagocytes in the lungs, such as dendritic cells …

Pleiotropic roles of LAMMER kinase, Lkh1 in stress responses and virulence of Cryptococcus neoformans

S Kwon, Y Choi, ES Kim, KT Lee, YS Bahn… - Frontiers in Cellular …, 2024 - frontiersin.org
Dual-specificity LAMMER kinases are highly evolutionarily conserved in eukaryotes and
play pivotal roles in diverse physiological processes, such as growth, differentiation, and …

Macropinocytosis as a potential mechanism driving neurotropism of Cryptococcus neoformans

DM Lanser, AB Bennett, K Vu, A Gelli - Frontiers in Cellular and …, 2023 - frontiersin.org
Cryptococcus neoformans can invade the central nervous system by crossing the blood-
brain barrier via a transcellular mechanism that relies on multiple host factors. In this …

Cerebral cryptococcosis associated with CD4+ T-lymphocytopenia in non-HIV patients after SARS-CoV-2 infection: case series in a specialized institute in Lima, Peru

JM Huamani-Córdova, M Hueda-Zavaleta… - Tropical Medicine and …, 2023 - mdpi.com
Cases of cryptococcosis have been reported in patients with COVID-19. The majority are in
patients with severe symptoms or who received immunosuppressants. However, there is still …