Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

Hematopoietic stem cells (HSCs) are responsible for lifelong production of blood cells. At the
same time, they must respond rapidly to acute needs such as infection or injury. Significant …

All hematopoietic and immune cells are continuously generated by hematopoietic stem cells
(HSCs) and hematopoietic progenitor cells (HPCs) through highly organized process of …

Expansion of myeloid cells associated with solid tumor development is a key contributor to
neoplastic progression. Despite their clinical relevance, the mechanisms controlling myeloid …

Host microbiota crosstalk is essential for the production and functional modulation of blood-
cell lineages. Whether, and if so how, the microbiota influences hematopoietic stem cells …

The bone marrow (BM) microenvironment, also called the BM niche, is essential for the
maintenance of fully functional blood cell formation (hematopoiesis) throughout life. Under …

Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal
and haematopoietic cells regulate their function. The steady state HSC niche has been …

During acute infectious and inflammatory conditions, a large number of neutrophils are in
high demand as they are consumed in peripheral organs. The hematopoietic system rapidly …

Hematopoiesis is the hierarchical process in which all lineages of blood cells are produced
by self-renewing hematopoietic stem cells (HSCs) in the bone marrow (BM). While the …

Inflammation exerts multiple effects on the early hematopoietic compartment. Best studied is
the role of proinflammatory cytokines in activating adult hematopoietic stem and progenitor …