Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection
F Caiado, EM Pietras, MG Manz - Journal of Experimental Medicine, 2021 - rupress.org
Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …
that involves activation and consumption of immune cells in order to reestablish and …
Inflammation: a key regulator of hematopoietic stem cell fate in health and disease
EM Pietras - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
Hematopoietic stem cells (HSCs) are responsible for lifelong production of blood cells. At the
same time, they must respond rapidly to acute needs such as infection or injury. Significant …
same time, they must respond rapidly to acute needs such as infection or injury. Significant …
[HTML][HTML] Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment
LV Kovtonyuk, K Fritsch, X Feng, MG Manz… - Frontiers in …, 2016 - frontiersin.org
All hematopoietic and immune cells are continuously generated by hematopoietic stem cells
(HSCs) and hematopoietic progenitor cells (HPCs) through highly organized process of …
(HSCs) and hematopoietic progenitor cells (HPCs) through highly organized process of …
Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils
AJ Casbon, D Reynaud, C Park… - Proceedings of the …, 2015 - National Acad Sciences
Expansion of myeloid cells associated with solid tumor development is a key contributor to
neoplastic progression. Despite their clinical relevance, the mechanisms controlling myeloid …
neoplastic progression. Despite their clinical relevance, the mechanisms controlling myeloid …
[HTML][HTML] The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow
Host microbiota crosstalk is essential for the production and functional modulation of blood-
cell lineages. Whether, and if so how, the microbiota influences hematopoietic stem cells …
cell lineages. Whether, and if so how, the microbiota influences hematopoietic stem cells …
[HTML][HTML] The hematopoietic bone marrow niche ecosystem
J Fröbel, T Landspersky, G Percin… - Frontiers in cell and …, 2021 - frontiersin.org
The bone marrow (BM) microenvironment, also called the BM niche, is essential for the
maintenance of fully functional blood cell formation (hematopoiesis) throughout life. Under …
maintenance of fully functional blood cell formation (hematopoiesis) throughout life. Under …
Dynamic responses of the haematopoietic stem cell niche to diverse stresses
Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal
and haematopoietic cells regulate their function. The steady state HSC niche has been …
and haematopoietic cells regulate their function. The steady state HSC niche has been …
[HTML][HTML] Regulation of emergency granulopoiesis during infection
During acute infectious and inflammatory conditions, a large number of neutrophils are in
high demand as they are consumed in peripheral organs. The hematopoietic system rapidly …
high demand as they are consumed in peripheral organs. The hematopoietic system rapidly …
Pro-inflammatory cytokines: emerging players regulating HSC function in normal and diseased hematopoiesis
C Mirantes, E Passegué, EM Pietras - Experimental cell research, 2014 - Elsevier
Hematopoiesis is the hierarchical process in which all lineages of blood cells are produced
by self-renewing hematopoietic stem cells (HSCs) in the bone marrow (BM). While the …
by self-renewing hematopoietic stem cells (HSCs) in the bone marrow (BM). While the …
Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis
A Collins, CA Mitchell, E Passegué - Journal of Experimental Medicine, 2021 - rupress.org
Inflammation exerts multiple effects on the early hematopoietic compartment. Best studied is
the role of proinflammatory cytokines in activating adult hematopoietic stem and progenitor …
the role of proinflammatory cytokines in activating adult hematopoietic stem and progenitor …