Cells transport and sort proteins and lipids, after their synthesis, to various destinations at
appropriate velocities in membranous organelles and protein complexes. Intracellular …

Various molecular cell biology and molecular genetic approaches have indicated significant
roles for kinesin superfamily proteins (KIFs) in intracellular transport and have shown that …

WE have hypothesized that end-to-end chromosome fusions observed in some tumours
could play a part in genetic instability associated with tumorigenesis and that fusion may …

We measured the force-velocity curves of single kinesin molecules attached to silica beads
movlng In an in vltro motility assay. Optical trapping interferometry was used to track …

The neuronal microtubule-associated protein tau plays an important role in establishing cell
polarity by stabilizing axonal microtubules that serve as tracks for motor-protein–driven …

Kinesin is a motor protein that uses energy derived from ATP hydrolysis to move organelles
along microtubules. Using a new technique for measuring the movement produced in vitro …

Mouse kif5B gene was disrupted by homologous recombination. kif5B−/− mice were
embryonic lethal with a severe growth retardation at 9.5–11.5 days postcoitum. To analyze …

Using quick-freeze/deep-etch electron microscopy of recombinant proteins adsorbed to
mica, we show that NSF, the oligomeric ATPase involved in membrane fusion, is a hollow …

To further elucidate the mechanism of organelle transport, we cloned a novel member of the
mouse kinesin superfamily, KIFlB. This N-terminal-type motor protein is expressed …

A single kinesin molecule can move “processively” along a microtubule for more than 1
micrometer before detaching from it. The prevailing explanation for this processive …