Brain NMDA receptors in schizophrenia and depression

A Adell - Biomolecules, 2020 - mdpi.com
N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP),
dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia …

[HTML][HTML] The role of parvalbumin interneurons in neurotransmitter balance and neurological disease

L Nahar, BM Delacroix, HW Nam - Frontiers in psychiatry, 2021 - frontiersin.org
While great progress has been made in the understanding of neurological illnesses, the
pathologies, and etiologies that give rise to these diseases still remain an enigma, thus, also …

[HTML][HTML] To approach or avoid: an introductory overview of the study of anxiety using rodent assays

M La-Vu, BC Tobias, PJ Schuette… - Frontiers in behavioral …, 2020 - frontiersin.org
Anxiety is a widely studied phenomenon in behavioral neuroscience, but the recent
literature lacks an overview of the major conceptual framework underlying anxiety research …

Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses

MV Fogaça, M Wu, C Li, XY Li, MR Picciotto… - Molecular …, 2021 - nature.com
Major depressive disorder (MDD) is associated with alterations of GABAergic interneurons,
notably somatostatin (Sst) as well as parvalbumin (Pvalb), in cortical brain areas. In addition …

Sex-dependent differences in animal cognition

A Koszałka, K Lustyk, K Pytka - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
The differences in cognitive processes driven by biological sex are the issues that have
gotten growing attention recently. Considering the increasing population suffering from …

Differential impact of stress and environmental enrichment on corticolimbic circuits

MA Smail, BL Smith, N Nawreen, JP Herman - … biochemistry and behavior, 2020 - Elsevier
Stress exposure can produce profound changes in physiology and behavior that can impair
health and well-being. Of note, stress exposure is linked to anxiety disorders and depression …

Stress-induced morphological, cellular and molecular changes in the brain—lessons learned from the chronic mild stress model of depression

AR Khan, L Geiger, O Wiborg, B Czéh - Cells, 2020 - mdpi.com
Major depressive disorder (MDD) is a severe illness imposing an increasing social and
economic burden worldwide. Numerous rodent models have been developed to investigate …

[HTML][HTML] Parvalbumin interneuron alterations in stress-related mood disorders: A systematic review

G Perlman, A Tanti, N Mechawar - Neurobiology of stress, 2021 - Elsevier
Stress-related psychiatric disorders including depression involve complex cellular and
molecular changes in the brain, and GABAergic signaling dysfunction is increasingly …

The DREADDful hurdles and opportunities of the chronic chemogenetic toolbox

M Claes, L De Groef, L Moons - Cells, 2022 - mdpi.com
The chronic character of chemogenetics has been put forward as one of the assets of the
technique, particularly in comparison to optogenetics. Yet, the vast majority of chemogenetic …

Parvalbumin-positive interneurons in the medial prefrontal cortex regulate stress-induced fear extinction impairments in male and female rats

AN Binette, J Liu, H Bayer, KL Crayton… - Journal of …, 2023 - Soc Neuroscience
Stress has profound effects on fear extinction, a form of learning that is essential to
behavioral therapies for trauma-related and stressor-related disorders. Recent work reveals …