Cancer cells propagated in three-dimensional (3D) culture systems exhibit physiologically
relevant cell–cell and cell–matrix interactions, gene expression and signaling pathway …

Multicellular spheroids are three dimensional in vitro microscale tissue analogs. The current
article examines the suitability of spheroids as an in vitro platform for testing drug delivery …

Advances in three-dimensional (3D) printing have enabled the direct assembly of cells and
extracellular matrix materials to form in vitro cellular models for 3D biology, the study of …

Cancer occurs when cells acquire genomic instability and inflammation, produce abnormal
levels of epigenetic factors/proteins and tumor suppressors, reprogram the energy …

The present article highlights the rationale, potential and flexibility of tumor spheroid mono-
and cocultures for implementation into state of the art anti-cancer therapy test platforms …

A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids
provide similar metabolism, proliferation, and species concentration gradients to those found …

Although used in academic research for several decades, 3D culture models have long
been regarded expensive, cumbersome and unnecessary in drug development processes …

The behaviour of cells cultured within three-dimensional (3D) structures rather than onto two-
dimensional (2D) culture plastic more closely reflects their in vivo responses. Consequently …

Adult gliomas are aggressive brain tumours associated with low patient survival rates and
limited life expectancy. The most important hallmark of this type of tumour is its invasive …

Multicellular tumor spheroids (MCTS) are used as organotypic models of normal and solid
tumor tissue. Traditional techniques for generating MCTS, such as growth on nonadherent …