Kinase inhibitors: the road ahead
FM Ferguson, NS Gray - Nature reviews Drug discovery, 2018 - nature.com
Receptor tyrosine kinase signalling pathways have been successfully targeted to inhibit
proliferation and angiogenesis for cancer therapy. However, kinase deregulation has been …
proliferation and angiogenesis for cancer therapy. However, kinase deregulation has been …
Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation
Poly [adenosine diphosphate (ADP)–ribose] polymerases (PARPs) are a family of enzymes
that modulate diverse biological processes through covalent transfer of ADP-ribose from the …
that modulate diverse biological processes through covalent transfer of ADP-ribose from the …
Alternative splicing and protein diversity: plants versus animals
S Chaudhary, W Khokhar, I Jabre, ASN Reddy… - Frontiers in plant …, 2019 - frontiersin.org
Plants, unlike animals, exhibit a very high degree of plasticity in their growth and
development and employ diverse strategies to cope with the variations during diurnal cycles …
development and employ diverse strategies to cope with the variations during diurnal cycles …
Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation
The transition from transcription initiation to elongation is a key regulatory step in gene
expression, which requires RNA polymerase II (pol II) to escape promoter proximal pausing …
expression, which requires RNA polymerase II (pol II) to escape promoter proximal pausing …
RNA Polymerase II cluster dynamics predict mRNA output in living cells
Protein clustering is a hallmark of genome regulation in mammalian cells. However, the
dynamic molecular processes involved make it difficult to correlate clustering with functional …
dynamic molecular processes involved make it difficult to correlate clustering with functional …
Histone marks in the 'driver's seat': functional roles in steering the transcription cycle
LA Gates, CE Foulds, BW O'malley - Trends in biochemical sciences, 2017 - cell.com
Particular chromatin modifications are associated with different states of gene transcription,
yet our understanding of which modifications are causal 'drivers' in promoting transcription is …
yet our understanding of which modifications are causal 'drivers' in promoting transcription is …
The La and related RNA‐binding proteins (LARPs): structures, functions, and evolving perspectives
RJ Maraia, S Mattijssen… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
La was first identified as a polypeptide component of ribonucleic protein complexes targeted
by antibodies in autoimmune patients and is now known to be a eukaryote cell‐ubiquitous …
by antibodies in autoimmune patients and is now known to be a eukaryote cell‐ubiquitous …
THZ1 reveals roles for Cdk7 in co-transcriptional capping and pausing
The Cdk7 subunit of TFIIH phosphorylates RNA polymerase II (Pol II) during initiation, and,
while recent studies show that inhibition of human Cdk7 negatively influences transcription …
while recent studies show that inhibition of human Cdk7 negatively influences transcription …
N6-methyladenosine in 7SK small nuclear RNA underlies RNA polymerase II transcription regulation
Summary N 6-methyladenosine (m 6 A) modifications play crucial roles in RNA metabolism.
How m 6 A regulates RNA polymerase II (RNA Pol II) transcription remains unclear. We find …
How m 6 A regulates RNA polymerase II (RNA Pol II) transcription remains unclear. We find …