Receptor tyrosine kinase signalling pathways have been successfully targeted to inhibit
proliferation and angiogenesis for cancer therapy. However, kinase deregulation has been …

The MYC protooncogene functions as a universal amplifier of transcription through
interaction with numerous factors and complexes that regulate almost every cellular process …

Poly [adenosine diphosphate (ADP)–ribose] polymerases (PARPs) are a family of enzymes
that modulate diverse biological processes through covalent transfer of ADP-ribose from the …

Plants, unlike animals, exhibit a very high degree of plasticity in their growth and
development and employ diverse strategies to cope with the variations during diurnal cycles …

The transition from transcription initiation to elongation is a key regulatory step in gene
expression, which requires RNA polymerase II (pol II) to escape promoter proximal pausing …

Protein clustering is a hallmark of genome regulation in mammalian cells. However, the
dynamic molecular processes involved make it difficult to correlate clustering with functional …

Particular chromatin modifications are associated with different states of gene transcription,
yet our understanding of which modifications are causal 'drivers' in promoting transcription is …

La was first identified as a polypeptide component of ribonucleic protein complexes targeted
by antibodies in autoimmune patients and is now known to be a eukaryote cell‐ubiquitous …

The Cdk7 subunit of TFIIH phosphorylates RNA polymerase II (Pol II) during initiation, and,
while recent studies show that inhibition of human Cdk7 negatively influences transcription …

Summary N 6-methyladenosine (m 6 A) modifications play crucial roles in RNA metabolism.
How m 6 A regulates RNA polymerase II (RNA Pol II) transcription remains unclear. We find …