Brucella MucR acts as an H-NS-like protein to silence virulence genes and structure the nucleoid

IS Barton, Z Ren, CB Cribb, JE Pitzer, I Baglivo… - MBio, 2023 - Am Soc Microbiol
Histone-like nucleoid structuring (H-NS) and H-NS-like proteins serve as global gene
silencers and work with antagonistic transcriptional activators (counter-silencers) to properly …

[HTML][HTML] The Transcription Factor CsgD Contributes to Engineered Escherichia coli Resistance by Regulating Biofilm Formation and Stress Responses

CH Yan, FH Chen, YL Yang, YF Zhan… - International Journal of …, 2023 - mdpi.com
The high cell density, immobilization and stability of biofilms are ideal characteristics for
bacteria in resisting antibiotic therapy. CsgD is a transcription activating factor that regulates …

[HTML][HTML] A LysR Transcriptional Regulator Manipulates Macrophage Autophagy Flux During Brucella Infection

L Zhang, S Yu, X Ning, H Fang, J Li, F Zhi… - Frontiers in Cellular …, 2022 - frontiersin.org
Brucella, the intracellular bacteria, have evolved subtle strategies to efficiently survive and
replicate in macrophages. However, the virulence effector proteins involved are still unclear …

[HTML][HTML] The Flagellar Transcriptional Regulator FtcR Controls Brucella melitensis 16M Biofilm Formation via a betI-Mediated Pathway in Response to Hyperosmotic …

J Guo, X Deng, Y Zhang, S Song, T Zhao… - International Journal of …, 2022 - mdpi.com
The expression of flagellar proteins in Brucella species likely evolved through genetic
transference from other microorganisms, and contributed to virulence, adaptability, and …

Molecular Insights into a Novel Cu (I)-Sensitive ArsR/SmtB Family Repressor in Extremophile Acidithiobacillus caldus

Y Qiu, Y Tong, H Yang, S Feng - Applied and Environmental …, 2023 - Am Soc Microbiol
Acidithiobacillus caldus is a common bioleaching bacterium that is inevitably exposed to
extreme copper stress in leachates. The ArsR/SmtB family of metalloregulatory repressors …

[PDF][PDF] Disrupting Bacterial Metal Ion Homeostasis to Break Antimicrobial Resistance

Z Marx - 2023 - ourarchive.otago.ac.nz
Antimicrobial resistance (AMR) describes a reduction in the efficacy of antimicrobial drugs
(eg, antibiotics) against pathogens (eg, bacteria). This is a clinical issue of growing concern …