[HTML][HTML] Viral hepatitis: Past, present, and future
MA Odenwald, S Paul - World Journal of Gastroenterology, 2022 - ncbi.nlm.nih.gov
Each hepatitis virus—Hepatitis A, B, C, D, E, and G—poses a distinct scenario to the patient
and clinician alike. Since the discovery of each virus, extensive knowledge regarding …
and clinician alike. Since the discovery of each virus, extensive knowledge regarding …
[HTML][HTML] Immunopathology of chronic hepatitis B infection: role of innate and adaptive immune response in disease progression
A Khanam, JV Chua, S Kottilil - International Journal of Molecular …, 2021 - mdpi.com
More than 250 million people are living with chronic hepatitis B despite the availability of
highly effective vaccines and oral antivirals. Although innate and adaptive immune cells play …
highly effective vaccines and oral antivirals. Although innate and adaptive immune cells play …
[HTML][HTML] Interferon and interferon-stimulated genes in HBV treatment
Q Li, B Sun, Y Zhuo, Z Jiang, R Li, C Lin, Y Jin… - Frontiers in …, 2022 - frontiersin.org
Human hepatitis B virus (HBV) is a small enveloped DNA virus with a complex life cycle. It is
the causative agent of acute and chronic hepatitis. HBV can resist immune system …
the causative agent of acute and chronic hepatitis. HBV can resist immune system …
Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection
J Schuhenn, TL Meister, D Todt… - Proceedings of the …, 2022 - National Acad Sciences
Type I interferons (IFN-I) exert pleiotropic biological effects during viral infections, balancing
virus control versus immune-mediated pathologies, and have been successfully employed …
virus control versus immune-mediated pathologies, and have been successfully employed …
HBV/pregenomic RNA increases the stemness and promotes the development of HBV‐related HCC through reciprocal regulation with insulin‐like growth factor 2 …
W Ding, M Wang, J Yu, G Huang, D Sun, L Liu… - …, 2021 - Wiley Online Library
Background and Aims HBV‐pgRNA (pregenomic RNA) has been proposed for predicting
the response of nucleos (t) ide analogue (NA) treatment, guiding discontinuation of NA …
the response of nucleos (t) ide analogue (NA) treatment, guiding discontinuation of NA …
[HTML][HTML] Innate immunity, inflammation, and intervention in HBV infection
G Yang, P Wan, Y Zhang, Q Tan, MS Qudus, Z Yue… - Viruses, 2022 - mdpi.com
Hepatitis B virus (HBV) infection is still one of the most dangerous viral illnesses. HBV infects
around 257 million individuals worldwide. Hepatitis B in many individuals ultimately …
around 257 million individuals worldwide. Hepatitis B in many individuals ultimately …
Functional comparison of interferon‐α subtypes reveals potent hepatitis B virus suppression by a concerted action of interferon‐α and interferon‐γ signaling
Background and Aims Interferon (IFN)‐α, composed of numerous subtypes, plays a crucial
role in immune defense. As the most studied subtype, IFN‐α2 has been used for treating …
role in immune defense. As the most studied subtype, IFN‐α2 has been used for treating …
[HTML][HTML] HBV/HIV coinfection: impact on the development and clinical treatment of liver diseases
Z Cheng, P Lin, N Cheng - Frontiers in medicine, 2021 - frontiersin.org
Hepatitis B virus (HBV) infection is a common contributor to chronic hepatitis, liver cirrhosis,
and hepatocellular carcinoma. Approximately 10% of people with human immunodeficiency …
and hepatocellular carcinoma. Approximately 10% of people with human immunodeficiency …
Novel therapeutic strategies for chronic hepatitis B
S Phillips, R Jagatia, S Chokshi - Virulence, 2022 - Taylor & Francis
The last few years have seen a resurgence of activity in the hepatitis B drug pipeline, with
many compounds in various stages of development. This review aims to provide a …
many compounds in various stages of development. This review aims to provide a …
[PDF][PDF] Type-I-IFN-stimulated gene TRIM5γ inhibits HBV replication by promoting HBx degradation
To understand the molecular mechanisms that mediate the anti-hepatitis B virus (HBV) effect
of interferon (IFN) therapy, we conduct high-throughput bimolecular fluorescence …
of interferon (IFN) therapy, we conduct high-throughput bimolecular fluorescence …