Microglia, being the resident immune cells of the central nervous system, play an important
role in maintaining tissue homeostasis and contributes towards brain development under …

A large body of experimental evidence suggests that neuroinflammation is a key
pathological event triggering and perpetuating the neurodegenerative process associated …

Huntington's disease (HD) is a fully penetrant neurodegenerative disease caused by a
dominantly inherited CAG trinucleotide repeat expansion in the huntingtin gene on …

Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

The triggering of innate immune mechanisms is emerging as a crucial component of major
neurodegenerative diseases. Microglia and other cell types in the brain can be activated in …

Abstract Nuclear Factor-Erythroid Factor 2 (Nrf2) is an important transcription factor that
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …

Huntington disease is devastating to patients and their families—with autosomal dominant
inheritance, onset typically in the prime of adult life, progressive course, and a combination …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

The complement system plays critical roles in development, homeostasis, and regeneration
in the central nervous system (CNS) throughout life; however, complement dysregulation in …

While peripheral immune access to the central nervous system (CNS) is restricted and tightly
controlled, the CNS is capable of dynamic immune and inflammatory responses to a variety …