Huntington disease is a neurodegenerative disorder caused by an expanded CAG repeat in
the Huntington disease gene. The symptomatic phase of the disease is defined by the onset …

The complement system, an essential tightly regulated innate immune system, is a key
regulator of normal central nervous system (CNS) development and function. However …

For almost three decades, Huntington's disease has been a prototype for the application of
genetic strategies to human disease. HD, the Huntington's disease gene, was the first …

Huntington's disease (HD) is a hereditary neurodegenerative disorder for which biological
indicators of disease progression, or disease stage, would be especially important for …

The complement system is an assembly of proteins that collectively participate in the
functions of the healthy and diseased brain. The complement system plays an important role …

Background Neuroinflammation may contribute to the pathogenesis of Huntington's disease,
given evidence of activated microglia and elevated levels of inflammatory molecules in …

Unintended weight loss frequently complicates the course of many neurodegenerative
disorders and can contribute substantially to both morbidity and mortality. This will be …

Background Huntington's disease (HD) is an autosomal dominant disease caused by an
abnormally high number of CAG repeats at the huntingtin-encoding gene, HTT. This genetic …

Levels of full-length huntingtin (FL htt) influence organ and body weight, independent of
polyglutamine length. The growth hormone-insulin like growth factor-1 (GH-IGF-1) axis is …

With several therapeutic approaches in development for Huntington's disease, there is a
need for easily accessible biomarkers to monitor disease progression and therapy …