Huntington's disease (HD) is an inherited disease that causes progressive nerve cell
degeneration. It is triggered by a mutation in the HTT gene that strongly influences functional …

Background Huntington's disease (HD) is a genetic neurodegenerative disorder
characterized by a triad of cognitive, psychiatric and motor symptoms. One of the main …

Neurodegenerative disorders such as Alzheimer's, Parkinson's, and Huntington's diseases
are highly prevalent and immensely destructive to the health and well-being of individuals …

Precision medicine has emerged as a central element of healthcare science. Complement, a
component of innate immunity known for centuries, has been implicated in the …

Huntington's disease (HD) is a progressive neurodegenerative disease caused by an
unstable CAG trinucleotide repeat expansion. The need for biomarkers of onset and …

Polyglutamine (polyQ) disorders share many similarities, such as a common mutation type in
unrelated human causative genes, neurological character, and certain aspects of …

J. Neurochem.(2010) 113, 1416–1425. Abstract Elevated concentrations of neurotoxic
metabolites of the kynurenine pathway (KP) of tryptophan degradation may play a causative …

Neurodegenerative disorders are a subset of disabling pathologies characterized, in part, by
a progressive and specific loss of certain brain cell populations. Current therapeutic …

Huntington's disease (HD) is an incurable neurodegenerative disorder caused by CAG
trinucleotide expansions in the huntingtin gene. Markers of both systemic and CNS immune …

Oxidative stress has long been implicated in the pathophysiology and progression of
Huntington's disease (HD). Uric acid (UA) is a naturally occurring antioxidant that is present …