Publisher Summary This chapter provides evidence that indicates a potential role for
superantigens in the pathogenesis of several human diseases. The term “superantigen” was …

The recent discovery of the mode of interaction between a group of microbial proteins known
as superantigens and the immune system has opened a wide area of investigation into the …

The structure of a bacterial superantigen, Staphylococcus aureus enterotoxin B, bound to a
human class II histocompatibility complex molecule (HLA-DR1) has been determined by X …

The three-dimensional structure of staphylococcal enterotoxin B, which is both a toxin and a
super-antigen, has been determined to a resolution of 2.5 Å. The unusual main-chain fold …

Background: Class II major histocompatibility complex (MHC) proteins are cell surface
glycoproteins that bind peptides and present them to T cells as part of the mechanism for …

Staphylococcal enterotoxins are prototype superantigens characterized by their ability to
bind to major histocompatibility complex (MHC) class II molecules and subsequently activate …

The superantigen staphylococcal enterotoxin A (SEA) binds to major histocompatibility
complex (MHC) class II molecules at two sites on either side of the peptide groove. Two …

Bacterial superantigens (SAgs) are potent activators of T lymphocytes and play a
pathophysiological role in Gram‐positive septic shock and food poisoning. To characterize …

Staphylococcus aureus strain D4508 is a toxic shock syndrome toxin 1-negative clinical
isolate from a nonmenstrual case of toxic shock syndrome (TSS). In the present study, we …

Kawasaki disease (KD) is a multisystem vasculitis and the leading cause of acquired heart
disease in children of the developed world. Lactobacillus casei cell wall extract‐induced …