Cancer is one of the leading causes of death worldwide. The tumour extracellular matrix
(ECM) has unique features in terms of composition and mechanical properties, resulting in a …

In this state-of-the-art review we detail the journey of xenotransplantation from its infancy,
detailing one of the first published cases and the subsequent journey the field took in its …

Natural killer (NK) cells play an important role in immune rejection in solid organ
transplantation. To mitigate human NK cell activation in xenotransplantation, introducing …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive lethal malignancy that
accounts for more than 90% of pancreatic cancer diagnoses. Our research is focused on the …

Cell transplantation provides a therapeutic alternative to whole organ transplantation in the
management of diseases arising from the absence or failure of specialized cells. Though …

The pig appears to be the most promising animal donor of organs for use in human
recipients. Among several types of pathogens found in pigs, one of the greatest problems is …

Telomere reprogramming and silencing of exogenous genes have been demonstrated in
mouse and human induced pluripotent stem cells (iPS cells). Pigs have the potential to …

Aim: The escalating demand for corneal transplants significantly surpasses the available
supply. To bridge this gap, we concentrated on ethical and sustainable corneal grafting …

Pigs are proposed to be suitable large animal models for test of the efficacy and safety of
induced pluripotent stem cells (iPSCs) for stem cell therapy, but authentic pig ES/iPS cell …

Xenotransplantation can provide a virtually limitless supply of cells, tissues and organs for a
variety of therapeutic procedures. Cells and tissues for use in human transplantation …