Top-down feedback in cortex is critical for guiding sensory processing, which has
prominently been formalized in the theory of hierarchical predictive coding (hPC). However …

Radial cell columns are a hallmark feature of cortical architecture in many mammalian
species. It has long been held, based on the lack of orientation columns, that such functional …

While sensory representations in the brain depend on context, it remains unclear how such
modulations are implemented at the biophysical level, and how processing layers further in …

Top-down projections convey a family of signals encoding previous experiences and current
aims to the sensory neocortex, where they converge with external bottom-up information to …

The deepest layer of the cortex (layer 6b [L6b]) contains relatively few neurons, but it is the
only cortical layer responsive to the potent wake-promoting neuropeptide orexin/hypocretin …

Accurate perception of the environment is a constructive process that requires integration of
external bottom-up sensory signals with internally generated top-down information. Decades …

Summary Layer 1 (L1) interneurons (INs) participate in various brain functions by gating
information flow in the neocortex, but their role in the medial entorhinal cortex (MEC) is still …

Memories are generally considered to be embodied in the connection strengths between
neurons. Finding the exact synaptic connections responsible for memories out of hundreds …

Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and
feedback axons where local inhibitory signaling can profoundly shape cortical processing …

Higher-order projections to sensory cortical areas converge on layer 1 (L1), the primary site
for integration of top-down information via the apical dendrites of pyramidal neurons and L1 …