The tetrahydroisoquinoline (THIQ) natural products constitute one of the largest families of
alkaloids and exhibit a wide range of structural diversity and biological activity. Ranging from …

Natural products and their structural analogues have historically made a major contribution
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …

BACKGROUND: Nature has been a source of medicinal products for millennia, with many
useful drugs developed from plant sources. Following discovery of the penicillins, drug …

Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Covering: through 2014 Many organisms team up with microbes for defense against
predators, parasites, parasitoids, or pathogens. Here we review the described protective …

Marine life forms are an important source of structurally diverse and biologically active
secondary metabolites, several of which have inspired the development of new classes of …

The declining trends in microbial metabolite and natural products research and the
refocusing of this research area are discussed. Renewing natural products research …

Actinomycetes are virtually unlimited sources of novel compounds with many therapeutic
applications and hold a prominent position due to their diversity and proven ability to …

Covering: 2011. Previous review: Nat. Prod. Rep., 2012, 29, 144–222. This review covers
the literature published in 2011 for marine natural products, with 870 citations (558 for the …

Interest in therapeutic discovery typically drives the preparation of natural product analogs,
but these undertakings contribute significant advances for synthetic chemistry as well. The …