Physiologically based kinetic (PBK) models for farm animals are of growing interest in food
and feed safety with key applications for regulated compounds including quantification of …

Background Many countries are increasingly prohibiting the addition of antibiotics in
livestock diets. Therefore, herb extracts have gradually drawn attention to substitute …

Physiologically based pharmacokinetic (PBPK) models for chemicals in food animals are a
useful tool in estimating chemical tissue residues and withdrawal intervals. Physiological …

Physiologically‐based pharmacokinetic (PBPK) models represent drug kinetics in one or
more 'real'organs (and hence require submodels of organs/tissues) and they describe …

Background: Remimazolam is a newly developed benzodiazepine as an alternative of
conventional sedatives in the procedure of anesthesia. For the purpose of evaluating the …

Cefquinome is widely used to treat respiratory tract diseases of swine. While extra-label
dosages of cefquinome could improve clinical efficacy, they might lead to excessively high …

Bioelectronic Medicine stands as an emerging field that rapidly evolves and offers distinctive
clinical benefits, alongside unique challenges. It consists of the modulation of the nervous …

Background CNS 7056 is a new short-acting esterase-metabolized benzodiazepine. We
report the first pharmacokinetic (PK) and pharmacodynamic (PD) study of CNS 7056 and its …

The contribution of the lymphatic systemto the absorption and systemic bioavailabilityof
Micrurus fulvius venom after subcutaneous (SC) administration was assessed using acentral …

This report is the third in a series of studies that aimed to compile physiological parameters
related to develop physiologically based pharmacokinetic (PBPK) models for drugs and …