Model‐based interspecies scaling of glucose homeostasis
O Alskär, MO Karlsson… - CPT: Pharmacometrics & …, 2017 - Wiley Online Library
Being able to scale preclinical pharmacodynamic response to clinical would be beneficial in
drug development. In this work, the integrated glucose insulin (IGI) model, developed on …
drug development. In this work, the integrated glucose insulin (IGI) model, developed on …
Apply a physiologically based pharmacokinetic model to promote the development of enrofloxacin granules: Predict withdrawal interval and toxicity dose
K Zhou, A Liu, W Ma, L Sun, K Mi, X Xu, SA Algharib… - Antibiotics, 2021 - mdpi.com
Enrofloxacin (ENR) granules were developed to prevent and control the infections caused
by foodborne zoonotic intestinal pathogens in our previous studies. To promote the further …
by foodborne zoonotic intestinal pathogens in our previous studies. To promote the further …
Investigation of hepatobiliary disposition of doxorubicin following intrahepatic delivery of different dosage forms
E Lilienberg, C Ebeling Barbier, R Nyman… - Molecular …, 2014 - ACS Publications
Unresectable, intermediate stage hepatocellular carcinoma (HCC) is often treated
palliatively in humans by doxorubicin (DOX). The drug is administered either as a drug …
palliatively in humans by doxorubicin (DOX). The drug is administered either as a drug …
Estimating tulathromycin withdrawal time in pigs using a physiologically based pharmacokinetics model
F Yang, XH Huang, GH Li, HJ Ni, YD Zhao… - Food Additives & …, 2013 - Taylor & Francis
A physiologically based pharmacokinetics model was developed to predict tulathromycin
concentrations in edible swine tissues. Physiological parameters included volumes of and …
concentrations in edible swine tissues. Physiological parameters included volumes of and …
[HTML][HTML] A One-Health evaluation of the burden of cystic echinococcosis and its prevention costs: Case study from a hypo-endemic area in Italy
An integrated model, based on a One Health approach, was implemented to estimate the
epidemiological and economic outcomes of cystic echinococcosis (CE) in Veneto region, an …
epidemiological and economic outcomes of cystic echinococcosis (CE) in Veneto region, an …
A physiologically based pharmacokinetic/pharmacodynamic model to determine dosage regimens and withdrawal intervals of aditoprim against Streptococcus suis
K Mi, L Sun, L Zhang, A Tang, X Tian, Y Hou… - Frontiers in …, 2024 - frontiersin.org
Introduction: Streptococcus suis (S. suis) is a zoonotic pathogen threatening public health.
Aditoprim (ADP), a novel veterinary medicine, exhibits an antibacterial effect against S. suis …
Aditoprim (ADP), a novel veterinary medicine, exhibits an antibacterial effect against S. suis …
A first-generation physiologically based pharmacokinetic (PBPK) model of alpha-tocopherol in human influenza vaccine adjuvant
MA Tegenge, RJ Mitkus - Regulatory Toxicology and Pharmacology, 2015 - Elsevier
Alpha (α)-tocopherol is a component of a new generation of squalene-containing oil-in-
water (SQ/W) emulsion adjuvants that have been licensed for use in certain influenza …
water (SQ/W) emulsion adjuvants that have been licensed for use in certain influenza …
Prediction of optimum supplemental heat for piglets
The thermal environment of farrowing facilities is generally controlled at the thermo-neutral
zone for sows (15° C to 19° C). This imposes thermal challenges for newborn piglets, which …
zone for sows (15° C to 19° C). This imposes thermal challenges for newborn piglets, which …
[HTML][HTML] Optimization of intrabone delivery of hematopoietic progenitor cells in a swine model using cell radiolabeling with [89] zirconium
Intrabone (IB) hematopoietic cell transplantation (HCT) of umbilical cord blood in humans
remains experimental and the technique has not been optimized. It is unknown whether …
remains experimental and the technique has not been optimized. It is unknown whether …
Relationship between coronary volume, myocardial mass, and post‐PCI fractional flow reserve
N Mileva, H Ohashi, P Paolisso… - Catheterization and …, 2023 - Wiley Online Library
Background Fractional flow reserve (FFR) measured after percutaneous coronary
intervention (PCI) carries prognostic information. Yet, myocardial mass subtended by a …
intervention (PCI) carries prognostic information. Yet, myocardial mass subtended by a …