Targeting interleukin-10 signalling for cancer immunotherapy, a promising and complicated task

G Ni, L Zhang, X Yang, H Li, B Ma… - Human vaccines & …, 2020 - Taylor & Francis
ABSTRACT Interleukin 10 (IL-10) belongs to IL-10 family cytokines that are critical for
maintaining the integrity of epithelial tissues, protecting pathogenic infection, and preventing …

[HTML][HTML] Screening for new macrophage therapeutics

CB Rodell, PD Koch, R Weissleder - Theranostics, 2019 - ncbi.nlm.nih.gov
Myeloid derived macrophages play a key role in many human diseases, and their
therapeutic modulation via pharmacological means is receiving considerable attention. Of …

Intratumoral injection of caerin 1.1 and 1.9 peptides increases the efficacy of vaccinated TC‐1 tumor‐bearing mice with PD‐1 blockade by modulating macrophage …

G Ni, X Yang, J Li, X Wu, Y Liu, H Li… - Clinical & …, 2021 - Wiley Online Library
Objectives Developing a vaccine formula that alters the tumor‐infiltrating lymphocytes to be
more immune active against a tumor is key to the improvement of clinical responses to …

Caerin 1.1/1.9 enhances antitumour immunity by activating the IFN-α response signalling pathway of tumour macrophages

X Yang, X Liu, J Li, P Zhang, H Li, G Chen, W Zhang… - Cancers, 2022 - mdpi.com
Simple Summary Cancer immunotherapy has been enabled by immune checkpoint
blockade, but is ineffective in many patients, mainly due to the high complexity of the …

Vaccinations for colorectal cancer: progress, strategies, and novel adjuvants

S Jiang, D Good, MQ Wei - International Journal of Molecular Sciences, 2019 - mdpi.com
Although cancer is a leading cause of death, significant breakthroughs have been made in
its treatment in recent years. In particular, increasingly effective cancer vaccines are being …

Tongue sole (Cynoglossus semilaevis) interleukin 10 receptors are involved in the immune response against bacterial infection

X Li, J Zhang - Developmental & Comparative Immunology, 2021 - Elsevier
Abstract Interleukin (IL)-10, an immune-regulatory cytokine, exerts various biological
functions through interaction with IL-10 receptors. In teleost, very limited functional studies …

Caerin 1 Peptides, the Potential Jack‐of‐All‐Trades for the Multiple Antibiotic‐Resistant Bacterial Infection Treatment and Cancer Immunotherapy

L Xiao, X Yang, J Li, P Zhang, S Tang… - BioMed Research …, 2022 - Wiley Online Library
Antibiotic resistance‐related bacterial infections and cancers become huge challenges in
human health in the 21st century. A number of naturally derived antimicrobial peptides …

Proteomics: Unraveling the Cross Talk Between Innate Immunity and Disease Pathophysiology, Diagnostics, and Treatment Options

IS Luz, R Takaya, DG Ribeiro, MS Castro… - … -Based Approaches for …, 2024 - Springer
Inflammation is crucial in diseases, and proteins play a key role in the interplay between
innate immunity and pathology. This review explores how proteomics helps understanding …

[PDF][PDF] Caerin 1.1/1.9 Enhances Antitumour Immunity by Activating the IFN-α Response Signalling Pathway of Tumour Macrophages. Cancers (Basel). 2022; 14 (23) …

X Yang, X Liu, J Li, P Zhang, H Li, G Chen, W Zhang… - 2022 - research.usc.edu.au
Macrophages are one of the essential components of the tumour microenvironment (TME) of
many cancers and show complex heterogeneity and functions. More recent research has …

Analysis of the CD8+ IL-10+ T cell response elicited by vaccination with the oncogenic tumor-self protein D52

CR Elizondo, JD Bright, JA Byrne… - Human vaccines & …, 2020 - Taylor & Francis
Development of cancer vaccines targeting tumor self-antigens is complex and challenging
due to the difficulty of overcoming immune tolerance to self-proteins. Vaccination against …