Targeting the gut and tumor microbiota in cancer

EM Park, M Chelvanambi, N Bhutiani, G Kroemer… - Nature medicine, 2022 - nature.com
Microorganisms within the gut and other niches may contribute to carcinogenesis, as well as
shaping cancer immunosurveillance and response to immunotherapy. Our understanding of …

The microbiome and human cancer

GD Sepich-Poore, L Zitvogel, R Straussman, J Hasty… - Science, 2021 - science.org
BACKGROUND Historical accounts linking cancer and microbes date as early as four
millennia ago. After establishment of the germ theory of infectious diseases, clinical research …

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

LY Zhao, JX Mei, G Yu, L Lei, WH Zhang… - … and Targeted Therapy, 2023 - nature.com
In the past period, due to the rapid development of next-generation sequencing technology,
accumulating evidence has clarified the complex role of the human microbiota in the …

Western-style diet, pks island-carrying Escherichia coli, and colorectal cancer: analyses from two large prospective cohort studies

K Arima, R Zhong, T Ugai, M Zhao, K Haruki, N Akimoto… - Gastroenterology, 2022 - Elsevier
Background & Aims Evidence supports a carcinogenic role of Escherichia coli carrying the
pks island that encodes enzymes for colibactin biosynthesis. We hypothesized that the …

Diagnostic and prognostic potential of the microbiome in ovarian cancer treatment response

AE Asangba, J Chen, KM Goergen, MC Larson… - Scientific reports, 2023 - nature.com
Ovarian cancer (OC) is the second most common gynecological malignancy and the fifth
leading cause of death due to cancer in women in the United States mainly due to the late …

Intratumoral microbiota: A new force in diagnosing and treating pancreatic cancer

Z Jiang, W Zhang, Z Zhang, G Sha, D Wang, D Tang - Cancer Letters, 2023 - Elsevier
Pancreatic cancer is an increasingly growing source of cancer-related deaths and is often
diagnosed at advanced stages. Its treatment is difficult because of the poor results of …

Computational methods and challenges in analyzing intratumoral microbiome data

Q Wang, Z Liu, A Ma, Z Li, B Liu, Q Ma - Trends in microbiology, 2023 - cell.com
The human microbiome is intimately related to cancer biology and plays a vital role in the
efficacy of cancer treatments, including immunotherapy. Extraordinary evidence has …

The effect of the intratumoral microbiome on tumor occurrence, progression, prognosis and treatment

F Gao, B Yu, B Rao, Y Sun, J Yu, D Wang… - Frontiers in …, 2022 - frontiersin.org
In the past few decades, great progress has been achieved in the understanding of
microbiome-cancer interactions. However, most of the studies have focused on the gut …

Tumor-associated microbiome: where do we stand?

M Oliva, N Mulet-Margalef, M Ochoa-De-Olza… - International Journal of …, 2021 - mdpi.com
The study of the human microbiome in oncology is a growing and rapidly evolving field. In
the past few years, there has been an exponential increase in the number of studies …

Urinary microbiota and bladder cancer: A systematic review and a focus on uropathogens

A Yacouba, MT Alou, JC Lagier, G Dubourg… - Seminars in Cancer …, 2022 - Elsevier
The higher incidence of bladder cancer in men has long been attributed to environmental
factors, including smoking. The fact that the sex ratio of bladder cancer remains consistently …