US FDA approved drugs from 2015–June 2020: a perspective
In the present work, we report compilation and analysis of 245 drugs, including small and
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …
A decade of FDA-approved drugs (2010–2019): trends and future directions
A total of 378 novel drugs and 27 biosimilars approved by the US Food and Drug
Administration (FDA) between 2010 and 2019 were evaluated according to approval …
Administration (FDA) between 2010 and 2019 were evaluated according to approval …
Tuberculosis drug discovery: challenges and new horizons
GFS Fernandes, AM Thompson… - Journal of Medicinal …, 2022 - ACS Publications
Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
FDA-approved trifluoromethyl group-containing drugs: a review of 20 years
AS Nair, AK Singh, A Kumar, S Kumar, S Sukumaran… - Processes, 2022 - mdpi.com
As people around the world regard 2020 as the year of COVID-19, the medical community
considers this year to be the second-best year, shared with the year 1996, with respect to the …
considers this year to be the second-best year, shared with the year 1996, with respect to the …
Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid …
Background Improved genetic understanding of Mycobacterium tuberculosis (MTB)
resistance to novel and repurposed anti-tubercular agents can aid the development of rapid …
resistance to novel and repurposed anti-tubercular agents can aid the development of rapid …
Fluorine-containing drugs approved by the FDA in 2019
H Mei, AM Remete, Y Zou, H Moriwaki, S Fustero… - Chinese Chemical …, 2020 - Elsevier
Eleven new fluorine-containing FDA-approved drugs have been profiled and details of their
discovery and preparation are discussed. Therapeutic areas include schizophrenia …
discovery and preparation are discussed. Therapeutic areas include schizophrenia …
QT effects of bedaquiline, delamanid, or both in patients with rifampicin-resistant tuberculosis: a phase 2, open-label, randomised, controlled trial
KE Dooley, SL Rosenkranz, F Conradie… - The Lancet Infectious …, 2021 - thelancet.com
Background Bedaquiline and delamanid are the first drugs of new classes registered for
tuberculosis treatment in 40 years. Each can prolong the QTc interval, with maximum effects …
tuberculosis treatment in 40 years. Each can prolong the QTc interval, with maximum effects …
[HTML][HTML] Pretomanid for tuberculosis: a systematic review
T Gils, L Lynen, BC de Jong, A Van Deun… - Clinical Microbiology and …, 2022 - Elsevier
Background Outcomes of treatment of tuberculosis patients with regimens including
pretomanid have not yet been systematically reviewed. Objectives To appraise existing …
pretomanid have not yet been systematically reviewed. Objectives To appraise existing …
Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies
Pretomanid is a nitroimidazole antimicrobial active against drug-resistant Mycobacterium
tuberculosis and approved in combination with bedaquiline and linezolid (BPaL) to treat …
tuberculosis and approved in combination with bedaquiline and linezolid (BPaL) to treat …
Recent developments of imidazo [1, 2-a] pyridine analogues as antituberculosis agents
S Samanta, S Kumar, EK Aratikatla… - RSC Medicinal …, 2023 - pubs.rsc.org
Over the past 2000 years, tuberculosis (TB) has killed more people than any other infectious
disease. In 2021, TB claimed 1.6 million lives worldwide, making it the second leading …
disease. In 2021, TB claimed 1.6 million lives worldwide, making it the second leading …