Heavy (excessive) levels of drinking and increased vulnerability to relapse represent
hallmark features of alcohol abuse disorders and alcoholism. The development of animal …

Paradigms used to study the response to and consequences of exposure to reward loss
have been underutilized in approaches to the psychobiology of substance use disorders …

Drug addiction is a syndrome of dysregulated motivation, evidenced by intense drug craving
and compulsive drug-seeking behavior. In the search for common neurobiological …

Background: Substance use disorders (SUD) are patterns of substance use leading to
severe impairment on social, working and economic levels. In vivo and clinical findings have …

Alcohol use disorder (AUD) and anxiety disorders are frequently comorbid and share
dysregulated neuroimmune-related pathways. Here, we used our established rat model of …

Early-life adversity is associated with increased risk for substance abuse in later life, with
women more likely to report past and current stress as a mediating factor in their substance …

Objectives: To explore whether varenicline (Chantix) showed more efficacy in treating
certain subgroups of patients. In a recent multisite trial, varenicline was shown to be effective …

Alcohol use disorder (AUD) remains a significant public health concern, affecting around 5%
of adults worldwide. Novel pathways of damage have been described during the last years …

The periaqueductal gray (PAG) is a complex mesencephalic structure involved in the
integration and execution of active and passive self-protective behaviors against imminent …

Background Binge drinking of alcohol during adolescence is a serious public health concern
with long‐term consequences, including increased pain, fear, and anxiety. The …