Mitochondria in health, disease, and aging
JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
Role of Nrf2 in aging, Alzheimer's and other neurodegenerative diseases
M George, M Tharakan, J Culberson, AP Reddy… - Ageing Research …, 2022 - Elsevier
Abstract Nuclear Factor-Erythroid Factor 2 (Nrf2) is an important transcription factor that
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …
[HTML][HTML] Genetic correlations between Alzheimer's disease and gut microbiome genera
D Cammann, Y Lu, MJ Cummings, ML Zhang… - Scientific Reports, 2023 - nature.com
A growing body of evidence suggests that dysbiosis of the human gut microbiota is
associated with neurodegenerative diseases like Alzheimer's disease (AD) via …
associated with neurodegenerative diseases like Alzheimer's disease (AD) via …
Mitophagy: A promising therapeutic target for neuroprotection during ageing and age‐related diseases
E Mishra, MK Thakur - British Journal of Pharmacology, 2023 - Wiley Online Library
Mitochondria and mitochondria‐mediated signalling pathways are known to control synaptic
signalling, as well as long‐lasting changes in neuronal structure and function. Mitochondrial …
signalling, as well as long‐lasting changes in neuronal structure and function. Mitochondrial …
Mitochondria in aging and Alzheimer's disease: focus on mitophagy
JA Pradeepkiran, J Baig, A Seman… - The …, 2024 - journals.sagepub.com
Alzheimer's disease (AD) is characterized by the accumulation of amyloid β and
phosphorylated τ protein aggregates in the brain, which leads to the loss of neurons. Under …
phosphorylated τ protein aggregates in the brain, which leads to the loss of neurons. Under …
Mitochondrial fission mediated by Drp1-Fis1 pathway and neurodegenerative diseases
W Shi, C Tan, C Liu, D Chen - Reviews in the Neurosciences, 2023 - degruyter.com
In recent years, the role of mitochondrial dynamics in neurodegenerative diseases has
becoming increasingly important. More and more evidences have shown that in pathological …
becoming increasingly important. More and more evidences have shown that in pathological …
[HTML][HTML] Regulation of mitochondrial dysfunction induced cell apoptosis is a potential therapeutic strategy for herbal medicine to treat neurodegenerative diseases
RL Li, LY Wang, HX Duan, Q Zhang, X Guo… - Frontiers in …, 2022 - frontiersin.org
Neurodegenerative disease is a progressive neurodegeneration caused by genetic and
environmental factors. Alzheimer's disease (AD), Parkinson's disease (PD), and …
environmental factors. Alzheimer's disease (AD), Parkinson's disease (PD), and …
Mitophagy and traumatic brain injury: regulatory mechanisms and therapeutic potentials
Y Luan, L Jiang, Y Luan, Y Xie… - … Medicine and Cellular …, 2023 - Wiley Online Library
Traumatic brain injury (TBI), a kind of external trauma‐induced brain function alteration, has
posed a financial burden on the public health system. TBI pathogenesis involves a …
posed a financial burden on the public health system. TBI pathogenesis involves a …
[HTML][HTML] The therapeutic value of Solanum steroidal (Glyco) alkaloids: a 10-year comprehensive review
JA Delbrouck, M Desgagné, C Comeau, K Bouarab… - Molecules, 2023 - mdpi.com
Steroidal (glycol) alkaloids S (G) As are secondary metabolites made of a nitrogen-
containing steroidal skeleton linked to a (poly) saccharide, naturally occurring in the …
containing steroidal skeleton linked to a (poly) saccharide, naturally occurring in the …
[HTML][HTML] Current advances in mitochondrial targeted interventions in Alzheimer's disease
T Sousa, PI Moreira, S Cardoso - Biomedicines, 2023 - mdpi.com
Alzheimer's disease is the most prevalent neurodegenerative disorder and affects the lives
not only of those who are diagnosed but also of their caregivers. Despite the enormous …
not only of those who are diagnosed but also of their caregivers. Despite the enormous …