mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond

ME Senti, LG Del Valle, RM Schiffelers - Advanced Drug Delivery Reviews, 2024 - Elsevier
Abstract mRNA-based vaccines are emerging as a promising alternative to standard cancer
treatments and the conventional vaccines. Moreover, the FDA-approval of three nucleic acid …

[HTML][HTML] Boosting vaccine effectiveness: the groundbreaking role of probiotics

M Abavisani, N Ebadpour, A Khoshrou… - Journal of Agriculture and …, 2024 - Elsevier
Probiotics, the health-promoting members of the gut microbiota, have been shown to
enhance mucosal and systemic immunity, stimulate cytokines, chemokines, and antibodies …

Layer-by-layer nanoparticle encapsulating all-trans retinoic acid and CpG as a mucosal adjuvant targeting colorectal cancer

S Mi, W Li, Y Wen, C Yang, S Liu, J Li, X Cheng… - Biomaterials …, 2024 - pubs.rsc.org
Colorectal cancer (CRC) ranks among the most prevalent cancers globally, demanding
innovative therapeutic strategies. Immunotherapy, a promising avenue, employs cancer …

The Platform Technology Approach to mRNA Product Development and Regulation

JH Skerritt, C Tucek-Szabo, B Sutton, T Nolan - Vaccines, 2024 - mdpi.com
mRNA-lipid nanoparticle (LNP) medicinal products can be considered a platform technology
because the development process is similar for different diseases and conditions, with …

Innovative Drug Modalities for the Treatment of Advanced Prostate Cancer

M Capuozzo, M Santorsola, M Ianniello, F Ferrara… - Diseases, 2024 - mdpi.com
Prostate cancer, a prevalent malignancy affecting the prostate gland, is a significant global
health concern. Androgen-deprivation therapy (ADT) has proven effective in controlling …

State-Of-The-Art Advancements on Cancer Vaccines and Biomarkers

S Strum, MH Andersen, IM Svane, LL Siu… - American Society of …, 2024 - ascopubs.org
The origins of cancer vaccines date back to the 1800s. Since then, there have been
significant efforts to generate vaccines against solid and hematologic malignancies using a …

Recent Findings on Therapeutic Cancer Vaccines: An Updated Review

S Sheikhlary, DH Lopez, S Moghimi, B Sun - Biomolecules, 2024 - mdpi.com
Cancer remains one of the global leading causes of death and various vaccines have been
developed over the years against it, including cell-based, nucleic acid-based, and viral …

Progress with the application of synthetic biology in designing of cancer vaccines

F Chao, W HUANG - Synthetic Biology Journal, 2024 - synbioj.cip.com.cn
The central dogma of biology, which delineates the flow of genetic information from DNA to
RNA to protein, along with the principles of cellular immunology, provides a foundational …

[HTML][HTML] Cancer Vaccines Designed Based the Nanoparticle and Tumor Cells for the Treatment of Tumors: A Perspective

QJ Wu, WL Lv - IET Nanobiotechnology, 2024 - hindawi.com
Cancer vaccines based on tumor cell components have shown promising results in animal
and clinical studies. The vaccine system contains abundant tumor antigen components …

Immunoinformatics Design and In Vivo Immunogenicity Evaluation of a Conserved CTL Multi-Epitope Vaccine Targeting HPV16 E5, E6, and E7 Proteins

N Guo, Z Niu, Z Yan, W Liu, L Shi, C Li, Y Yao, L Shi - Vaccines, 2024 - mdpi.com
Human papillomavirus type 16 (HPV16) infection is responsible for more than 50% of global
cervical cancer cases. The development of a vaccine based on cytotoxic T-lymphocyte (CTL) …