Nrf2–ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

I Buendia, P Michalska, E Navarro, I Gameiro… - Pharmacology & …, 2016 - Elsevier
Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …

[HTML][HTML] The anti-inflammatory properties of phytochemicals and their effects on epigenetic mechanisms involved in TLR4/NF-κB-mediated inflammation

HA Saleh, MH Yousef, A Abdelnaser - Frontiers in immunology, 2021 - frontiersin.org
Innate immune response induces positive inflammatory transducers and regulators in order
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …

[HTML][HTML] The integrative role of sulforaphane in preventing inflammation, oxidative stress and fatigue: A review of a potential protective phytochemical

RT Ruhee, K Suzuki - Antioxidants, 2020 - mdpi.com
Cruciferous vegetables hold a myriad of bioactive molecules that are renowned for
possessing unique medicinal benefits. Sulforaphane (SFN) is one of the potential …

Reactivity and stability of glucosinolates and their breakdown products in foods

FS Hanschen, E Lamy, M Schreiner… - Angewandte Chemie …, 2014 - Wiley Online Library
The chemistry of glucosinolates and their behavior during food processing is very complex.
Their instability leads to the formation of a bunch of breakdown and reaction products that …

Sulforaphane protects against cardiovascular disease via Nrf2 activation

Y Bai, X Wang, S Zhao, C Ma, J Cui… - Oxidative medicine and …, 2015 - Wiley Online Library
Cardiovascular disease (CVD) causes an unparalleled proportion of the global burden of
disease and will remain the main cause of mortality for the near future. Oxidative stress plays …

[HTML][HTML] Dietary glucosinolates sulforaphane, phenethyl isothiocyanate, indole-3-carbinol/3, 3′-diindolylmethane: Antioxidative stress/inflammation, Nrf2, epigenetics …

F Fuentes, X Paredes-Gonzalez, ANT Kong - Current pharmacology …, 2015 - Springer
Glucosinolates are a group of sulfur-containing glycosides found in many plant species,
including cruciferous vegetables such as broccoli, cabbage, Brussels sprouts, and …

[HTML][HTML] Isothiocyanates, Nitriles, and Epithionitriles from Glucosinolates Are Affected by Genotype and Developmental Stage in Brassica oleracea Varieties

FS Hanschen, M Schreiner - Frontiers in plant science, 2017 - frontiersin.org
Vegetables of the Brassica oleracea group, such as broccoli, cauliflower, and cabbage, play
an important role for glucosinolate consumption in the human diet. Upon maceration of the …

Curcumin induces Nrf2 nuclear translocation and prevents glomerular hypertension, hyperfiltration, oxidant stress, and the decrease in antioxidant enzymes in 5/6 …

E Tapia, V Soto, KM Ortiz-Vega… - Oxidative medicine …, 2012 - Wiley Online Library
Renal injury resulting from renal ablation induced by 5/6 nephrectomy (5/6NX) is associated
with oxidant stress, glomerular hypertension, hyperfiltration, and impaired Nrf2‐Keap1 …

[HTML][HTML] The glucosinolates: a sulphur glucoside family of mustard anti-tumour and antimicrobial phytochemicals of potential therapeutic application

J Melrose - Biomedicines, 2019 - mdpi.com
This study reviewed aspects of the biology of two members of the glucosinolate family,
namely sinigrin and glucoraphanin and their anti-tumour and antimicrobial properties …

The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders

B Gao, A Doan, BM Hybertson - Clinical pharmacology: advances …, 2014 - Taylor & Francis
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2; encoded in humans by the NFE2L2 gene) is
a transcription factor that regulates the gene expression of a wide variety of cytoprotective …