Cerebral small vessel disease (SVD) is common during ageing and can present as stroke,
cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently …

Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …

Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

The R47H variant of triggering receptor expressed on myeloid cells 2 (TREM2) increases
the risk of Alzheimer's disease (AD). To investigate potential mechanisms, we analyzed …

Background Considerable overlap exists between the risk factors of dementia and cerebral
small vessel disease (SVD). However, studies remain limited to older cohorts wherein …

Background To promote the development of effective therapies, there is an important need
to characterize the full spectrum of neuropathological changes associated with Alzheimer's …

Cerebral microvascular disease (MVD) is an important cause of vascular cognitive
impairment. MVD is heterogeneous in aetiology, ranging from universal ageing to the …

Small vessel strokes (SVS) and intracerebral haemorrhages (ICH) are acute outcomes of
cerebral small vessel disease (SVD). Genetic studies combining both phenotypes have …

The worldwide increase in the incidence of obesity and cardiovascular and
neurodegenerative diseases, eg Alzheimer's disease, is related to many factors, including …

Patients with Alzheimer's disease (AD) often present with imaging features indicative of
small-vessel injury, among which, white-matter hyperintensities (WMHs) are the most …