Despite extensive breakthroughs in chemistry, molecular biology, and genetics in the last
decades, the success rates of drug development projects remain low. To improve …

Glycosaminoglycans (GAGs) constitute a considerable fraction of the glycoconjugates found
on cellular membranes and in the extracellular matrix of virtually all mammalian tissues. The …

Membrane proteins play critical roles in disease and in the disposition of many
pharmaceuticals. A prime example is P-glycoprotein (Pgp) which moves a diverse range of …

Drug absorption in the intestine is tightly related to drug-induced nephrotoxicity, which is a
relatively common side effect in clinical practice. It highlights a great need to develop …

The P-glycoprotein (Pgp) transporter plays a central role in drug disposition by effluxing a
chemically diverse range of drugs from cells through conformational changes and ATP …

Colchicine is increasingly used as the number of potential indications expands. However, it
also has a narrow therapeutic index that is associated with bothersome to severe side …

This article features selected findings from the senior author and colleagues dating back to
1978 and covering approximately three-fourths of the 60 years since the discovery of …

P-glycoprotein (Pgp) plays a pivotal role in drug bioavailability and multi-drug resistance
development. Understanding the protein's activity and designing effective drugs require …

The membrane-bound P-glycoprotein (Pgp) transporter plays a major role in human disease
and drug disposition because of its ability to efflux a chemically diverse range of drugs …

P-glycoprotein (Pgp) is an ATP-binding cassette (ABC) transporter that plays a major role in
cardiovascular drug disposition by effluxing a chemically and structurally diverse range of …