Background Non-alcoholic fatty liver disease (NAFLD) is defined by the abundance of lipid
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …

Following detection of bacteria, macrophages switch their metabolism from oxidative
respiration through the tricarboxylic acid cycle to high-rate aerobic glycolysis. This …

In response to inflammatory activation by pathogens, macrophages accumulate triglycerides
in intracellular lipid droplets. The mechanisms underlying triglyceride accumulation and its …

Perturbations in lipid homeostasis combined with conditions favoring oxidative stress
constitute a hallmark of the inflammatory response. In this review we focus on the most …

All living organisms can make lipid droplets (LDs), intracellular oil-in-water droplets,
surrounded by a phospholipid and protein monolayer. LDs are at the nexus of cellular lipid …

Neutrophils are the most abundant human white blood cell and constitute a first line of
defense in the innate immune response. Neutrophils are short-lived cells and thus the …

Lipid droplets are fat storage organelles ubiquitously distributed across the eukaryotic
kingdom. They have a central role in regulating lipid metabolism and undergo a dynamic …

Lipid droplets have a unique structure among organelles consisting of a dense hydrophobic
core of neutral lipids surrounded by a single layer of phospholipids decorated with various …

During development, the human fetus accrues the highest proportion of fat of all mammals.
Precursors of fat lobules can be found at week 14 of pregnancy. Thereafter, they expand …

Suppressive regulatory T cell (Treg) differentiation is controlled by diverse immunometabolic
signaling pathways and intracellular metabolites. Here we show that cell-permeable α …