The role of cytokines and chemokines in severe acute respiratory syndrome coronavirus 2 infections

RJ Hsu, WC Yu, GR Peng, CH Ye, SY Hu… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …

Current state of Alzheimer's fluid biomarkers

JL Molinuevo, S Ayton, R Batrla, MM Bednar… - Acta …, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and
heterogeneous pathophysiology. The number of people living with AD is predicted to …

Systemic IL-15, IFN-γ, and IP-10/CXCL10 signature associated with effective immune response to SARS-CoV-2 in BNT162b2 mRNA vaccine recipients

C Bergamaschi, E Terpos, M Rosati, M Angel, J Bear… - Cell reports, 2021 - cell.com
Early responses to vaccination are important for shaping both humoral and cellular
protective immunity. Dissecting innate vaccine signatures may predict immunogenicity to …

The vaginal microbiome and preterm birth

JM Fettweis, MG Serrano, JP Brooks, DJ Edwards… - Nature medicine, 2019 - nature.com
The incidence of preterm birth exceeds 10% worldwide. There are significant disparities in
the frequency of preterm birth among populations within countries, and women of African …

The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans

JC Doloff, O Veiseh, R de Mezerville, M Sforza… - Nature biomedical …, 2021 - nature.com
Silicone is widely used in chronic implants and is generally perceived to be safe. However,
textured breast implants have been associated with immune-related complications …

Impact of mRNA chemistry and manufacturing process on innate immune activation

J Nelson, EW Sorensen, S Mintri, AE Rabideau… - Science …, 2020 - science.org
Messenger RNA (mRNA) represents an attractive therapeutic modality for potentially a wide
range of clinical indications but requires uridine chemistry modification and/or tuning of the …

The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
In patients with severe COVID‐19, acute respiratory distress syndrome (ARDS), multiple
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …

The chemokine superfamily revisited

A Zlotnik, O Yoshie - Immunity, 2012 - cell.com
The chemokine superfamily consists of a large number of ligands and receptors. At first
glance, this family appears redundant and their ligand-receptor relationships promiscuous …

The systematic effect of mesenchymal stem cell therapy in critical COVID-19 patients: a prospective double controlled trial

G Adas, Z Çukurova, KK Yasar, R Yilmaz… - Cell …, 2021 - journals.sagepub.com
The aim of this clinical trial was to control the cytokine storm by administering mesenchymal
stem cells (MSCs) to critically-ill COVID-19 patients, to evaluate the healing effect, and to …

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

R Edahiro, Y Shirai, Y Takeshima, S Sakakibara… - Nature …, 2023 - nature.com
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory
syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T …