Recent progress in functionalized and targeted polymersomes and chimeric polymeric nanotheranostic platforms for cancer therapy

M Beygi, F Oroojalian, SS Hosseini… - Progress in Materials …, 2023 - Elsevier
The majority of advances in cancer therapy have been achieved based on developments in
public awareness, as well as novel diagnostic and therapeutic modalities. Treatment …

Polymersome Membrane Engineering with Active Targeting or Controlled Permeability for Responsive Drug Delivery

A Kayani, A Raza, J Si, D Dutta, Q Zhou… - Biomacromolecules, 2023 - ACS Publications
Polymersomes have been extensively investigated for drug delivery as nanocarriers for two
decades due to a series of advantages including high stability under physiological …

Biomimetic dendritic polymeric microspheres induce enhanced T cell activation and expansion for adoptive tumor immunotherapy

H Yang, L Sun, R Chen, Z Xiong, W Yu, Z Liu, H Chen - Biomaterials, 2023 - Elsevier
A variety of bioactive materials are currently developed to expand T cells ex vivo for adoptive
T cell immunotherapy, also known as called artificial antigen-presenting cells (aAPCs) …

[HTML][HTML] Nanocarriers for delivery of siRNA as gene silencing mediator

A Morales-Becerril, L Aranda-Lara, K Isaac-Olivé… - EXCLI …, 2022 - ncbi.nlm.nih.gov
The term nanocarrier refers to sub-micrometric particles of less than 100 nm, designed to
transport, distribute, and release nanotechnology-based drug delivery systems. siRNA …

Block Length‐Dependent Protein Fouling on Poly (2‐oxazoline)‐Based Polymersomes: Influence on Macrophage Association and Circulation Behavior

A Najer, A Belessiotis‐Richards, H Kim, C Saunders… - Small, 2022 - Wiley Online Library
Polymersomes are vesicular structures self‐assembled from amphiphilic block copolymers
and are considered an alternative to liposomes for applications in drug delivery …

[HTML][HTML] Polymersomes with splenic avidity target red pulp myeloid cells for cancer immunotherapy

AC Wauters, JF Scheerstra, MMT van Leent… - Nature …, 2024 - nature.com
Regulating innate immunity is an emerging approach to improve cancer immunotherapy.
Such regulation requires engaging myeloid cells by delivering immunomodulatory …

Preparation of polymersomes from synthesized hyaluronic acid-graft-poly (ε-caprolactone) copolymers for drug delivery to the brain

B Kiani-Dehkordi, A Vatanara, M Amini… - Materials Today …, 2023 - Elsevier
The application of amphiphilic block copolymer for drug delivery has received immense
attention in recent years. Polymersomes are favorable types of polymeric systems that can …

Differences in human plasma protein interactions between various polymersomes and stealth liposomes as observed by fluorescence correlation spectroscopy

A Najer, O Rifaie‐Graham, J Yeow… - Macromolecular …, 2023 - Wiley Online Library
A significant factor hindering the clinical translation of polymersomes as vesicular
nanocarriers is the limited availability of comparative studies detailing their interaction with …

[HTML][HTML] Current perspectives on synthetic compartments for biomedical applications

L Heuberger, M Korpidou, OM Eggenberger… - International Journal of …, 2022 - mdpi.com
Nano-and micrometer-sized compartments composed of synthetic polymers are designed to
mimic spatial and temporal divisions found in nature. Self-assembly of polymers into …

pH and ROS Responsiveness of Polymersome Nanovaccines for Antigen and Adjuvant Codelivery: An In Vitro and In Vivo Comparison

E Jäger, O Ilina, Y Dölen, M Valente… - …, 2024 - ACS Publications
The antitumor immunity can be enhanced through the synchronized codelivery of antigens
and immunostimulatory adjuvants to antigen-presenting cells, particularly dendritic cells …