Chaperone-mediated autophagy (CMA) is a lysosomal pathway of proteolysis that is
responsible for the degradation of 30% of cytosolic proteins under conditions of prolonged …

Most of the examples of protein translocation across a membrane (such as the import of
classical secretory proteins into the endoplasmic reticulum, import of proteins into …

Proteins: Structure and Function is a comprehensive introduction to the study of proteins and
their importance to modern biochemistry. Each chapter addresses the structure and function …

Central to understanding how nanoscale objects interact with living matter is the need for
reproducible and verifiable data that can be interpreted with confidence. Likely this will be …

Chaperone-mediated autophagy is one of several lysosomal pathways of proteolysis. This
pathway is activated by physiological stresses such as prolonged starvation. Cytosolic …

The two main proteolytic machineries of eukaryotic cells, lysosomes and proteasomes,
receive substrates by different routes. Polyubiquitination targets proteins for proteasomal …

A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …

Mammals survive starvation by activating proteolysis and lipolysis in many different tissues.
These responses are triggered, at least in part, by changing hormonal and neural statuses …

Reactive oxygen species (ROS)‐induced mitochondrial abnormalities may have important
consequences in the pathogenesis of degenerative diseases and cancer. Vitamin C is an …

When taking up the gauntlet of studying membrane protein functionality, scientists are
provided with a plethora of advantages, which can be exploited for the synthesis of these …