Approximately one third of newly discovered drug molecules show insufficient water
solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems …

The solubility behaviour of drugs remains one of the most challenging aspects in formulation
development. With the advent of combinatorial chemistry and high throughput screening, the …

Of the thousands of novel compounds that a drug discovery project team invents and that
bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution …

In this review we will discuss recent advances in computational prediction of solubility in
water-based solvents. Our focus is set on recent advances in predictions of biorelevant …

The recent impact of the Biopharmaceutics Classification System (BCS) and the
Biopharmaceutics Drug Disposition Classification System (BDDCS) on relevant scientific …

Accurate prediction of the in vivo biopharmaceutical performance of oral drug formulations is
critical to efficient drug development. Traditionally, in vitro evaluation of oral drug …

Cell-free permeation systems are gaining interest in drug discovery and development as
tools to obtain a reliable prediction of passive intestinal absorption without the …

Simulation of gastrointestinal conditions is essential to adequately predict the in vivo
behavior of drug formulations. To reduce the size and number of human studies required to …

Pharmaceutical solid oral dosage forms must undergo dissolution in the intestinal fluids of
the gastrointestinal tract before they can be absorbed and reach the systemic circulation …

Purpose The aim of this study was to update the compositions of biorelevant media to
represent the composition and physical chemical characteristics of the gastrointestinal fluids …