Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology

L Reyes, D Herrera, E Kozarov… - Journal of clinical …, 2013 - Wiley Online Library
Objective The objective of this review was to perform a systematic evaluation of the literature
reporting current scientific evidence for periodontal bacteria as contributors to …

Activation and resolution of periodontal inflammation and its systemic impact

H Hasturk, A Kantarci - Periodontology 2000, 2015 - Wiley Online Library
Inflammation is a highly organized event impacting upon organs, tissues and biological
systems. Periodontal diseases are characterized by dysregulation or dysfunction of …

Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response

V Blasco-Baque, L Garidou, C Pomié, Q Escoula… - Gut, 2017 - gut.bmj.com
Objective To identify a causal mechanism responsible for the enhancement of insulin
resistance and hyperglycaemia following periodontitis in mice fed a fat-enriched diet. Design …

Intracellular Porphyromonas gingivalis Promotes the Tumorigenic Behavior of Pancreatic Carcinoma Cells

JM Gnanasekaran, A Binder Gallimidi, E Saba, K Pandi… - Cancers, 2020 - mdpi.com
Porphyromonas gingivalis is a member of the dysbiotic oral microbiome associated with oral
inflammation and periodontal disease. Intriguingly, epidemiological studies link P. gingivalis …

Alzheimer's disease-like neurodegeneration in Porphyromonas gingivalis infected neurons with persistent expression of active gingipains

U Haditsch, T Roth, L Rodriguez… - Journal of …, 2020 - content.iospress.com
Background: Porphyromonas gingivalis (P. gingivalis) and its gingipain virulence factors
have been identified as pathogenic effectors in Alzheimer's disease (AD). In a recent study …

Mechanisms of vascular damage by systemic dissemination of the oral pathogen Porphyromonas gingivalis

C Farrugia, GP Stafford, J Potempa… - The FEBS …, 2021 - Wiley Online Library
Several studies have shown a clear association between periodontal disease and increased
risk of cardiovascular disease. Porphyromonas gingivalis (Pg), a key oral pathogen, and its …

Porphyromonas gingivalis traffics into endoplasmic reticulum-rich-autophagosomes for successful survival in human gingival epithelial cells

K Lee, JAS Roberts, CH Choi, KR Atanasova, Ö Yilmaz - Virulence, 2018 - Taylor & Francis
Porphyromonas gingivalis, an opportunistic pathogen usurps gingival epithelial cells (GECs)
as primary intracellular niche for its colonization in the oral mucosa. However, the precise …

Local and Systemic Effects of Porphyromonas gingivalis Infection

WA Chen, Y Dou, HM Fletcher, DS Boskovic - Microorganisms, 2023 - mdpi.com
Porphyromonas gingivalis, a gram-negative anaerobe, is a leading etiological agent in
periodontitis. This infectious pathogen can induce a dysbiotic, proinflammatory state within …

[HTML][HTML] Outer membrane vesicles of Porphyromonas gingivalis: Novel communication tool and strategy

H Okamura, K Hirota, K Yoshida, Y Weng, Y He… - … Dental Science Review, 2021 - Elsevier
Extracellular vesicles (EVs) have been recognized as a universal method of cellular
communications and are reportedly produced in bacteria, archaea, and eukaryotes …

[HTML][HTML] Infectious burden and atherosclerosis: A clinical issue

R Sessa, M Di Pietro, S Filardo… - World Journal of Clinical …, 2014 - ncbi.nlm.nih.gov
Atherosclerotic cardiovascular diseases, chronic inflammatory diseases of multifactorial
etiology, are the leading cause of death worldwide. In the last decade, more infectious …