Human embryonic, fetal, and adult hemoglobins have different subunit interface strengths. Correlation with lifespan in the red cell
LR Manning, JE Russell, JC Padovan, BT Chait… - Protein …, 2007 - Wiley Online Library
The different types of naturally occurring, normal human hemoglobins vary in their tetramer–
dimer subunit interface strengths (stabilities) by three orders of magnitude in the liganded …
dimer subunit interface strengths (stabilities) by three orders of magnitude in the liganded …
Energetic differences at the subunit interfaces of normal human hemoglobins correlate with their developmental profile
LR Manning, JE Russell, AM Popowicz… - Biochemistry, 2009 - ACS Publications
A previously unrecognized function of normal human hemoglobins occurring during protein
assembly is described, ie self-regulation of subunit pairings and their durations arising from …
assembly is described, ie self-regulation of subunit pairings and their durations arising from …
Effective Utilization of Molecular Genetic Screening of Patients with Sickle Cell Disease and Beta Thalassemia Major in Saudi Arabia
R Zahed - 2023 - etheses.whiterose.ac.uk
Hereditary blood diseases are prevalent in the Kingdom of Saudi Arabia. The majority of
these blood disorders are sickle cell disease and β-thalassemia with variants located on the …
these blood disorders are sickle cell disease and β-thalassemia with variants located on the …
Intrinsic regulation of hemoglobin expression by variable subunit interface strengths
JM Manning, AM Popowicz, JC Padovan… - The FEBS …, 2012 - Wiley Online Library
The expression of the six types of human Hb subunits over time is currently considered to be
regulated mainly by transcription factors that bind to upstream control regions of the gene …
regulated mainly by transcription factors that bind to upstream control regions of the gene …