NK cell-based cancer immunotherapy: from basic biology to clinical development
S Liu, V Galat, Y Galat4, YKA Lee… - Journal of hematology & …, 2021 - Springer
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …
immune activation against abnormal cells. Different from events required for T cell activation …
Exploring the NK cell platform for cancer immunotherapy
JA Myers, JS Miller - Nature reviews Clinical oncology, 2021 - nature.com
Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that are
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …
CAR-NK cells: A promising cellular immunotherapy for cancer
Natural Killer (NK) cells and CD8+ cytotoxic T cells are two types of immune cells that can
kill target cells through similar cytotoxic mechanisms. With the remarkable success of …
kill target cells through similar cytotoxic mechanisms. With the remarkable success of …
NK cells for cancer immunotherapy
N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …
associated with oncogenic transformation. This property, which is unique among immune …
Natural killer cells in clinical development as non-engineered, engineered, and combination therapies
N Lamers-Kok, D Panella, AM Georgoudaki… - Journal of Hematology & …, 2022 - Springer
Natural killer (NK) cells are unique immune effectors able to kill cancer cells by direct
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …
Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy
A Yilmaz, H Cui, MA Caligiuri, J Yu - Journal of hematology & oncology, 2020 - Springer
Natural killer (NK) cells are a critical component of the innate immune system. Chimeric
antigen receptors (CARs) re-direct NK cells toward tumor cells carrying corresponding …
antigen receptors (CARs) re-direct NK cells toward tumor cells carrying corresponding …
iPSC-derived natural killer cell therapies-expansion and targeting
Treatment of cancer with allogeneic natural killer (NK) cell therapies has seen rapid
development, especially use against hematologic malignancies. Clinical trials of NK cell …
development, especially use against hematologic malignancies. Clinical trials of NK cell …
CAR-NK cells: from natural basis to design for kill
Chimeric antigen receptors (CARs) are fusion proteins with an extracellular antigen
recognition domain and numerous intracellular signaling domains that have been …
recognition domain and numerous intracellular signaling domains that have been …
Developmental and functional control of natural killer cells by cytokines
Y Wu, Z Tian, H Wei - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells are effective in combating infections and tumors and as such are
tempting for adoptive transfer therapy. However, they are not homogeneous but can be …
tempting for adoptive transfer therapy. However, they are not homogeneous but can be …
NK cell-based immunotherapy for cancer
F Fang, W Xiao, Z Tian - Seminars in immunology, 2017 - Elsevier
Natural killer (NK) cells can induce an antigen-independent immune response against
malignant cells. A growing number of scientific reports and clinical studies have shown …
malignant cells. A growing number of scientific reports and clinical studies have shown …