NK cell-based cancer immunotherapy: from basic biology to clinical development

S Liu, V Galat, Y Galat4, YKA Lee… - Journal of hematology & …, 2021 - Springer
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …

Exploring the NK cell platform for cancer immunotherapy

JA Myers, JS Miller - Nature reviews Clinical oncology, 2021 - nature.com
Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that are
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …

CAR-NK cells: A promising cellular immunotherapy for cancer

G Xie, H Dong, Y Liang, JD Ham, R Rizwan, J Chen - EBioMedicine, 2020 - thelancet.com
Natural Killer (NK) cells and CD8+ cytotoxic T cells are two types of immune cells that can
kill target cells through similar cytotoxic mechanisms. With the remarkable success of …

NK cells for cancer immunotherapy

N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

Natural killer cells in clinical development as non-engineered, engineered, and combination therapies

N Lamers-Kok, D Panella, AM Georgoudaki… - Journal of Hematology & …, 2022 - Springer
Natural killer (NK) cells are unique immune effectors able to kill cancer cells by direct
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …

Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy

A Yilmaz, H Cui, MA Caligiuri, J Yu - Journal of hematology & oncology, 2020 - Springer
Natural killer (NK) cells are a critical component of the innate immune system. Chimeric
antigen receptors (CARs) re-direct NK cells toward tumor cells carrying corresponding …

iPSC-derived natural killer cell therapies-expansion and targeting

BH Goldenson, P Hor, DS Kaufman - Frontiers in immunology, 2022 - frontiersin.org
Treatment of cancer with allogeneic natural killer (NK) cell therapies has seen rapid
development, especially use against hematologic malignancies. Clinical trials of NK cell …

CAR-NK cells: from natural basis to design for kill

MB Khawar, H Sun - Frontiers in immunology, 2021 - frontiersin.org
Chimeric antigen receptors (CARs) are fusion proteins with an extracellular antigen
recognition domain and numerous intracellular signaling domains that have been …

Developmental and functional control of natural killer cells by cytokines

Y Wu, Z Tian, H Wei - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells are effective in combating infections and tumors and as such are
tempting for adoptive transfer therapy. However, they are not homogeneous but can be …

NK cell-based immunotherapy for cancer

F Fang, W Xiao, Z Tian - Seminars in immunology, 2017 - Elsevier
Natural killer (NK) cells can induce an antigen-independent immune response against
malignant cells. A growing number of scientific reports and clinical studies have shown …