NOD-like receptor family pyrin domain containing 3 (NLRP3) is an intracellular receptor that
senses foreign pathogens and endogenous danger signals. It assembles with apoptosis …

Studies on genetic–epigenetic interactions, including the mapping of methylation
quantitative trait loci (mQTLs) and haplotype-dependent allele-specific DNA methylation …

The Million Veteran Program (MVP), initiated by the Department of Veterans Affairs (VA),
aims to collect biosamples with consent from at least one million veterans. Presently, blood …

Inflammasome is a cytoplasmic multiprotein complex that facilitates the clearance of
exogenous microorganisms or the recognition of endogenous danger signals, which is …

Management of RA patients has significantly improved over the past decades. However, a
substantial proportion of patients is difficult-to-treat (D2T), remaining symptomatic after …

Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects~ 1% of the
Caucasian population. Over the last decades, the availability of biological drugs targeting …

Endogenous DNA derived from the nuclei or mitochondria is released into the bloodstream
following cell damage or death. Extracellular DNA, called cell-free DNA (cfDNA), is …

Rheumatoid arthritis (RA) is the most common inflammatory arthropathy worldwide. Possible
manifestations of RA can be represented by a wide variability of symptoms, clinical forms …

Background Anti‐tumor necrosis factor‐α (TNF‐α) is used for the treatment of severe cases
of IBD, including Crohn's disease (CD) and ulcerative colitis (UC). However, one‐third of the …

Background Ankylosing spondylitis (AS) results from the combined effects of susceptibility
genes and environmental factors. Polymorphisms in genes regulating inflammation may …