The effect of β-tubulin-specific antisense oligonucleotide encapsulated in different cationic liposomes on the supression of intracellular L. Donovani parasites in vitro
D Dasgupta, S Adhya, MK Basu - The journal of biochemistry, 2002 - jstage.jst.go.jp
An antisense oligonucleotide(20 mer) targeted to the parasite ƒÀ-tubulin gene and encap
sulated in cationic liposomes, was used to test its antileishmanial activity in vitro. Cat ionic …
sulated in cationic liposomes, was used to test its antileishmanial activity in vitro. Cat ionic …
Leishmania phagolysosome: drug trafficking and protein sorting across the compartment
P Chakraborty, MK Basu - Critical reviews in microbiology, 1997 - Taylor & Francis
Survival or destruction of intramacrophage pathogen Leishmania depends in part on
modulation of their host cell phagosome, capabilities of the infected macrophages to present …
modulation of their host cell phagosome, capabilities of the infected macrophages to present …
Engineered nucleic acids and methods of use thereof
S Bancel, JP Schrum, A Aristarkhov - US Patent 10,751,386, 2020 - Google Patents
PTJWIQPHWPFNBW-GBNDHIKLSA-N Pseudouridine Chemical compound O [C@@ H] 1
[C@ H](O)[C@@ H](CO) O [C@ H] 1C1= CNC (= O) NC1= O PTJWIQPHWPFNBW …
[C@ H](O)[C@@ H](CO) O [C@ H] 1C1= CNC (= O) NC1= O PTJWIQPHWPFNBW …
Phosphorothioate oligonucleotides derived from human immunodeficiency virus type 1 (HIV-1) primer tRNALys3 are strong inhibitors of HIV-1 reverse transcriptase …
R El Dirani-Diab, L Sarih-Cottin, B Delord… - Antimicrobial agents …, 1997 - Am Soc Microbiol
Retroviral reverse transcriptase (RT) is involved in the selection of a specific tRNA primer
which initiates proviral DNA minus-strand synthesis. Studies of the interactions between …
which initiates proviral DNA minus-strand synthesis. Studies of the interactions between …
Enhanced activity of antisense phosphorothioate oligos against Leishmania amastigotes: augmented uptake of oligo, ribonuclease H activation, and efficient target …
M Mishra, JM Porter-Kelley, PK Singh… - Biochemical …, 2001 - Elsevier
Leishmania, a parasitic protozoan, infects human macrophages, often causing severe
morbidity and mortality. The pathogenic form of this parasite, the amastigote, lives inside the …
morbidity and mortality. The pathogenic form of this parasite, the amastigote, lives inside the …
Design and application of a peptide nucleic acid sequence targeting the p75 neurotrophin receptor
IK Cheah, SS Cheema, SJ Langford, EC Lopes… - Bioorganic & medicinal …, 2003 - Elsevier
Novel antisense peptide nucleic acid (PNA) constructs targeting p75NTR as a potential
therapeutic strategy for amyotrophic lateral sclerosis (ALS) were designed, synthesised and …
therapeutic strategy for amyotrophic lateral sclerosis (ALS) were designed, synthesised and …
Silica nanowire conjugated with loop-shaped oligonucleotides: A new structure to silence cysteine proteinase gene in Leishmania tropica
The main aim of this study was to evaluate the capability of silica nanowire conjugated with
loop-shaped oligonucleotides (SNWCLSOs) to silence cysteine proteinase b (Cpb) gene in …
loop-shaped oligonucleotides (SNWCLSOs) to silence cysteine proteinase b (Cpb) gene in …
[HTML][HTML] Double hairpin complexes allow accommodation of all four base pairs in triple helices containing both DNA and RNA strands
E Pascolo, JJ Toulmé - Journal of Biological Chemistry, 1996 - ASBMB
We investigated the binding of an antisense oligodeoxynucleotide to a stem-loop structure
corresponding to the mini-exon sequence of the protozoan parasite Leishmania …
corresponding to the mini-exon sequence of the protozoan parasite Leishmania …
Increased efficacy of antileishmanial antisense phosphorothioate oligonucleotides in Leishmania amazonensis overexpressing ribonuclease H
M Mishra, JR Bennett, G Chaudhuri - Biochemical pharmacology, 2001 - Elsevier
Ribonuclease H (RNase H), an enzyme that cleaves an RNA sequence base-paired with a
complementary DNA sequence, is proposed to be the mediator of antisense …
complementary DNA sequence, is proposed to be the mediator of antisense …
Modified polynucleotides for the production of secreted proteins
S Bancel, T Chakraborty, A De Fougerolles… - US Patent …, 2017 - Google Patents
2015-10-02 Assigned to MODERNA THERAPEUTICS, INC. reassignment MODERNA
THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …