Interleukin-12 induces IFN-γ secretion and STAT signaling implying its potential regulation of Th1 cell response in Nile tilapia

H Gao, K Li, K Ai, M Geng, Y Cao, D Wang… - Fish & Shellfish …, 2023 - Elsevier
As a pleiotropic cytokine consisting of IL-12p35 and IL-12p40, Interleukin-12 (IL-12) features
in inflammation regulation and anti-bacterial immunity. While IL-12 homologs have been …

Nocardia rubra cell‐wall skeleton influences the development of cervical carcinoma by promoting the antitumor effect of macrophages and dendritic cells

S Zhang, H Wang, Y Liu, T Tao, Z Zeng… - Cancer …, 2022 - Wiley Online Library
Background As an immune enhancer, Nocardia rubra cell‐wall skeleton (Nr‐CWS) has
been used to treat persistent human papillomavirus infection and cervical precancerous …

IL-12-Overexpressed Nanoparticles Suppress the Proliferation of Melanoma Through Inducing ICD and Activating DC, CD8+ T, and CD4+ T Cells

HH Shen, JF Peng, RR Wang, PY Wang… - International Journal …, 2024 - Taylor & Francis
Purpose The drug resistance and low response rates of immunotherapy limit its application.
This study aimed to construct a new nanoparticle (CaCO3-polydopamine-polyethylenimine …

IL-12 conditioning of peripheral blood mononuclear cells from breast cancer patients promotes the zoledronate-induced expansion of γδ T cells in vitro and enhances …

L Assy, SM Khalil, M Attia, ML Salem - International Immunopharmacology, 2023 - Elsevier
Background In a series of our preclinical studies, we have reported that conditioning of α/β
CD8+ T cells in vitro with interleukin-12 (IL-12) during their expansion improves their homing …

[HTML][HTML] Upregulation of CD86 and IL-12 by rhododendrol in THP-1 cells cocultured with melanocytes through ROS and ATP

Y Katahira, E Sakamoto, A Watanabe… - Journal of …, 2022 - Elsevier
Background The tyrosinase inhibitor rhododendrol (RD), used as a skin whitening agent,
reportedly has the potential to induce leukoderma. Objective Although an immune response …