The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types
arranged in characteristic positions. During development, these different types of neurons …

Neurobiologists have long sought to understand how circuits in the nervous system are
organized to generate the precise neural outputs that underlie particular behaviours. The …

Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type
atlases of the mouse spinal cord have been published in recent years but have not been …

The coordinated spatial and temporal regulation of gene expression in the vertebrate neural
tube determines the identity of neural progenitors and the function and physiology of the …

Syncytial skeletal muscle cells contain hundreds of nuclei in a shared cytoplasm. We
investigated nuclear heterogeneity and transcriptional dynamics in the uninjured and …

Locomotion in mammals relies on a central pattern-generating circuitry of spinal
interneurons established during development that coordinates limb movement. These …

Little is known about the organizational and functional connectivity of the corticospinal (CS)
circuits that are essential for voluntary movement. Here, we map the connectivity between …

All forms of locomotion are repetitive motor activities that require coordinated bilateral
activation of muscles. The executive elements of locomotor control are networks of spinal …

The exteroceptive somatosensory system is important for reflexive and adaptive behaviors
and for the dynamic control of movement in response to external stimuli. This review outlines …

The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different
CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy …