Subpopulations of sensory neurons in the dorsal root ganglion (DRG) can be characterized
on the basis of sensory modalities that convey distinct peripheral stimuli, but the molecular …

Mutations in the human and mouse PTF1A/Ptf1a genes result in permanent diabetes
mellitus and cerebellar agenesis. We show that Ptf1a is present in precursors to GABAergic …

Locomotion is common to all animals and is essential for survival. Neural circuits located in
the spinal cord have been shown to be necessary and sufficient for the generation and …

Accurate motor performance depends on the integration in spinal microcircuits of sensory
feedback information. Hand grasp is a skilled motor behavior known to require cutaneous …

Walking is a key motor behaviour of limbed animals, executed by contraction of functionally
antagonistic muscle groups during swing and stance phases. Nevertheless, neuronal …

Characterizing epigenetic heterogeneity at the cellular level is a critical problem in the
modern genomics era. Assays such as single cell ATAC-seq (scATAC-seq) offer an …

Animals depend on sensory feedback from mechanosensory afferents for the dynamic
control of movement. This sensory feedback needs to be selectively modulated in a task-and …

We used conditional knockout strategies in mice to determine the developmental events and
gene expression program regulated by the LIM-homeodomain factor Islet1 in developing …

Neural progenitor cell grafts form new relays across sites of spinal cord injury (SCI). Using a
panel of neuronal markers, we demonstrate that spinal neural progenitor grafts to sites of …

Most neurons in vertebrates make a developmental choice between two principal
neurotransmitter phenotypes (glutamatergic versus GABAergic). Here we show that the …