[HTML][HTML] Precision radiotherapy for non-small cell lung cancer

WC Yang, FM Hsu, PC Yang - Journal of Biomedical Science, 2020 - Springer
Precision medicine is becoming the standard of care in anti-cancer treatment. The
personalized precision management of cancer patients highly relies on the improvement of …

Management of brain metastases in tyrosine kinase inhibitor–naïve epidermal growth factor receptor–mutant non–small-cell lung cancer: a retrospective multi …

WJ Magnuson, NH Lester-Coll, AJ Wu… - Journal of clinical …, 2017 - ascopubs.org
Purpose Stereotactic radiosurgery (SRS), whole-brain radiotherapy (WBRT), and epidermal
growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are treatment options for …

[HTML][HTML] Mechanisms and perspective treatment of radioresistance in non-small cell lung cancer

T Zhou, LY Zhang, JZ He, ZM Miao, YY Li… - Frontiers in …, 2023 - frontiersin.org
Radiotherapy is the major treatment of non-small cell lung cancer (NSCLC). The
radioresistance and toxicity are the main obstacles that leading to therapeutic failure and …

Extended Survival and Prognostic Factors for Patients With ALK-Rearranged Non–Small-Cell Lung Cancer and Brain Metastasis

KL Johung, N Yeh, NB Desai, TM Williams… - Journal of Clinical …, 2016 - ascopubs.org
Purpose We performed a multi-institutional study to identify prognostic factors and determine
outcomes for patients with ALK-rearranged non–small-cell lung cancer (NSCLC) and brain …

Impact of deferring radiation therapy in patients with epidermal growth factor receptor–mutant non-small cell lung cancer who develop brain metastases

WJ Magnuson, JT Yeung, PD Guillod… - International Journal of …, 2016 - Elsevier
Purpose To perform a retrospective analysis of patients with epidermal growth factor
receptor (EGFR)-mutant lung adenocarcinoma who developed brain metastases (BM) to …

Significance of targeted therapy and genetic alterations in EGFR, ALK, or KRAS on survival in patients with non–small cell lung cancer treated with radiotherapy for …

KS Mak, JF Gainor, A Niemierko, KS Oh… - Neuro …, 2015 - academic.oup.com
Background We determined the impact of genetic alterations in EGFR, ALK, or KRAS on
survival after radiotherapy for brain metastases in non–small cell lung cancer (NSCLC) …

Heavy charged particles: does improved precision and higher biological effectiveness translate to better outcome in patients?

M Durante, J Debus - Seminars in radiation oncology, 2018 - Elsevier
Protons are the most common charged particles used in oncology. Acceleration of heavier
ions requires larger accelerators and is more expensive, yet heavy nuclei share the same …

[HTML][HTML] Prognostic scores for brain metastasis patients: use in clinical practice and trial design

VA Venur, MS Ahluwalia - Chinese clinical oncology, 2015 - cco.amegroups.org
Brain metastases (BM) are the most serious neurological complication of cancer that results
in significant morbidity and mortality in these patients. The most common primary …

[HTML][HTML] Ononin promotes radiosensitivity in lung cancer by inhibiting HIF-1α/VEGF pathway

YM Zhang, ZM Miao, YP Chen, ZB Song, YY Li, ZW Liu… - Phytomedicine, 2024 - Elsevier
Background In our previous study, we provided evidence that Astragalus mongholicus
Bunge (AM) and its extracts possess a protective capability against radiation-induced …

[HTML][HTML] Clinical and preclinical outcomes of combining targeted therapy with radiotherapy

M Elbanna, NN Chowdhury, R Rhome… - Frontiers in …, 2021 - frontiersin.org
In the era of precision medicine, radiation medicine is currently focused on the precise
delivery of highly conformal radiation treatments. However, the tremendous developments in …