The concept of an epigenetic landscape describing potential cellular fates arising from
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …

Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …

Alterations in microRNAs (miRNAs) expression are causative in the initiation and
progression of human cancers. The molecular events responsible for the widespread …

Malignant renal tumours represent 5% of childhood cancers and include types with likely
different aetiology: Wilms tumour (WT), rhabdoid renal tumour, kidney sarcomas and renal …

Childhood malignancies are rarely related to known environmental exposures, and it has
become increasingly evident that inherited genetic factors play a substantial causal role …

Adult cancers often arise from premalignant clonal expansions. Whether the same is true of
childhood tumors has been unclear. To investigate whether Wilms tumor (nephroblastoma; a …

Mutation accumulation in stem cells has been associated with cancer risk. However, the
presence of numerous mutant clones in healthy tissues has raised the question of what …

MicroRNAs (miRNAs) belong to a class of endogenous small noncoding RNAs that regulate
gene expression at the posttranscriptional level, through both translational repression and …

Progresses over the past years have extensively improved our capacity to use genome-
scale analyses—including high-density genotyping and exome and genome sequencing …

With the development of RNA modification research, the importance of N6-methyladenosine
(m6A) in tumors cannot be ignored. m6A promotes the self-renewal of tumor stem cells and …