Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

JS Bhatti, A Sehrawat, J Mishra, IS Sidhu… - Free Radical Biology …, 2022 - Elsevier
Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …

[HTML][HTML] Regulation of Nrf2 by mitochondrial reactive oxygen species in physiology and pathology

S Kasai, S Shimizu, Y Tatara, J Mimura, K Itoh - Biomolecules, 2020 - mdpi.com
Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling
molecules that control various cellular functions. Nrf2 governs the gene expression of …

[HTML][HTML] Redox mechanism of reactive oxygen species in exercise

F He, J Li, Z Liu, CC Chuang, W Yang, L Zuo - Frontiers in physiology, 2016 - frontiersin.org
It is well known that regular exercise can benefit health by enhancing antioxidant defenses
in the body. However, unaccustomed and/or exhaustive exercise can generate excessive …

Exercise for prevention and relief of cardiovascular disease: prognoses, mechanisms, and approaches

D Tian, J Meng - Oxidative Medicine and Cellular Longevity, 2019 - Wiley Online Library
This review is aimed at summarizing the new findings about the multiple benefits of exercise
on cardiovascular disease (CVD). We pay attention to the prevalence and risk factors of …

[HTML][HTML] Exercise-stimulated ROS sensitive signaling pathways in skeletal muscle

J Bouviere, RS Fortunato, C Dupuy… - Antioxidants, 2021 - mdpi.com
Physical exercise represents a major challenge to whole-body homeostasis, provoking
acute and adaptative responses at the cellular and systemic levels. Different sources of …

An injectable dual‐function hydrogel protects against myocardial ischemia/reperfusion injury by modulating ROS/NO disequilibrium

T Hao, M Qian, Y Zhang, Q Liu, AC Midgley… - Advanced …, 2022 - Wiley Online Library
Acute myocardial infarction (MI) is the leading cause of death worldwide. Exogenous
delivery of nitric oxide (NO) to the infarcted myocardium has proven to be an effective …

[HTML][HTML] Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights

SA Mason, AJ Trewin, L Parker, GD Wadley - Redox biology, 2020 - Elsevier
Antioxidant supplements are commonly consumed by endurance athletes to minimize
exercise-induced oxidative stress, with the intention of enhancing recovery and improving …

[HTML][HTML] Molecular mechanisms underlying cardiac adaptation to exercise

RB Vega, JP Konhilas, DP Kelly, LA Leinwand - Cell metabolism, 2017 - cell.com
Exercise elicits coordinated multi-organ responses including skeletal muscle, vasculature,
heart, and lung. In the short term, the output of the heart increases to meet the demand of …

Nuclear factor erythroid‐derived 2‐like 2 (NFE2L2, Nrf2) mediates exercise‐induced mitochondrial biogenesis and the anti‐oxidant response in mice

TL Merry, M Ristow - The Journal of physiology, 2016 - Wiley Online Library
Key points Reactive oxygen species (ROS) and nitric oxide (NO) regulate exercise‐induced
nuclear factor erythroid 2‐related factor 2 (NFE2L2) expression in skeletal muscle. NFE2L2 …

[HTML][HTML] Nrf2 mediates redox adaptations to exercise

AJ Done, T Traustadóttir - Redox biology, 2016 - Elsevier
The primary aim of this review is to summarize the current literature on the effects of acute
exercise and regular exercise on nuclear factor erythroid 2-related factor 2 (Nrf2) activity and …