Intranasal drug delivery: opportunities and toxicologic challenges during drug development

LA Keller, O Merkel, A Popp - Drug delivery and translational research, 2022 - Springer
Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has
increased. This review article summarises information on intranasal administration for local …

[HTML][HTML] An update on psychopharmacological treatment of autism spectrum disorder

R Aishworiya, T Valica, R Hagerman, B Restrepo - Neurotherapeutics, 2023 - Elsevier
While behavioral interventions remain the mainstay of treatment of autism spectrum disorder
(ASD), several potential targeted treatments addressing the underlying neurophysiology of …

Intranasal oxytocin in children and adolescents with autism spectrum disorder

L Sikich, A Kolevzon, BH King… - … England Journal of …, 2021 - Mass Medical Soc
Background Experimental studies and small clinical trials have suggested that treatment
with intranasal oxytocin may reduce social impairment in persons with autism spectrum …

Theory of mind is not theory of emotion: A cautionary note on the Reading the Mind in the Eyes Test.

BFM Oakley, R Brewer, G Bird… - Journal of abnormal …, 2016 - psycnet.apa.org
The ability to represent mental states (theory of mind [ToM]) is crucial in understanding
individual differences in social ability and social impairments evident in conditions such as …

Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology

OD Howes, M Rogdaki, JL Findon… - Journal of …, 2018 - journals.sagepub.com
An expert review of the aetiology, assessment, and treatment of autism spectrum disorder,
and recommendations for diagnosis, management and service provision was coordinated …

Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism

KJ Parker, O Oztan, RA Libove… - Proceedings of the …, 2017 - National Acad Sciences
Autism spectrum disorder (ASD) is characterized by core social deficits. Prognosis is poor, in
part, because existing medications target only associated ASD features. Emerging evidence …

The effect of oxytocin nasal spray on social interaction deficits observed in young children with autism: a randomized clinical crossover trial

CJ Yatawara, SL Einfeld, IB Hickie, TA Davenport… - Molecular …, 2016 - nature.com
Interventions for autism are limited. The synthetic hormone oxytocin may provide a potential
treatment to improve core social and behavioral difficulties in autism, but its efficacy has yet …

Autism spectrum disorder in adults: diagnosis, management, and health services development

CM Murphy, CE Wilson, DM Robertson… - Neuropsychiatric …, 2016 - Taylor & Francis
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized
by pervasive difficulties since early childhood across reciprocal social communication and …

[HTML][HTML] Autism, oxytocin and interoception

E Quattrocki, K Friston - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
Autism is a pervasive developmental disorder characterized by profound social and verbal
communication deficits, stereotypical motor behaviors, restricted interests, and cognitive …

Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring

R Tyzio, R Nardou, DC Ferrari, T Tsintsadze… - Science, 2014 - science.org
We report that the oxytocin-mediated neuroprotective γ-aminobutyric acid (GABA) excitatory-
inhibitory shift during delivery is abolished in the valproate and fragile X rodent models of …