Intranasal drug delivery: opportunities and toxicologic challenges during drug development
LA Keller, O Merkel, A Popp - Drug delivery and translational research, 2022 - Springer
Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has
increased. This review article summarises information on intranasal administration for local …
increased. This review article summarises information on intranasal administration for local …
[HTML][HTML] An update on psychopharmacological treatment of autism spectrum disorder
R Aishworiya, T Valica, R Hagerman, B Restrepo - Neurotherapeutics, 2023 - Elsevier
While behavioral interventions remain the mainstay of treatment of autism spectrum disorder
(ASD), several potential targeted treatments addressing the underlying neurophysiology of …
(ASD), several potential targeted treatments addressing the underlying neurophysiology of …
Intranasal oxytocin in children and adolescents with autism spectrum disorder
L Sikich, A Kolevzon, BH King… - … England Journal of …, 2021 - Mass Medical Soc
Background Experimental studies and small clinical trials have suggested that treatment
with intranasal oxytocin may reduce social impairment in persons with autism spectrum …
with intranasal oxytocin may reduce social impairment in persons with autism spectrum …
Theory of mind is not theory of emotion: A cautionary note on the Reading the Mind in the Eyes Test.
BFM Oakley, R Brewer, G Bird… - Journal of abnormal …, 2016 - psycnet.apa.org
The ability to represent mental states (theory of mind [ToM]) is crucial in understanding
individual differences in social ability and social impairments evident in conditions such as …
individual differences in social ability and social impairments evident in conditions such as …
Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology
An expert review of the aetiology, assessment, and treatment of autism spectrum disorder,
and recommendations for diagnosis, management and service provision was coordinated …
and recommendations for diagnosis, management and service provision was coordinated …
Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism
Autism spectrum disorder (ASD) is characterized by core social deficits. Prognosis is poor, in
part, because existing medications target only associated ASD features. Emerging evidence …
part, because existing medications target only associated ASD features. Emerging evidence …
The effect of oxytocin nasal spray on social interaction deficits observed in young children with autism: a randomized clinical crossover trial
CJ Yatawara, SL Einfeld, IB Hickie, TA Davenport… - Molecular …, 2016 - nature.com
Interventions for autism are limited. The synthetic hormone oxytocin may provide a potential
treatment to improve core social and behavioral difficulties in autism, but its efficacy has yet …
treatment to improve core social and behavioral difficulties in autism, but its efficacy has yet …
Autism spectrum disorder in adults: diagnosis, management, and health services development
CM Murphy, CE Wilson, DM Robertson… - Neuropsychiatric …, 2016 - Taylor & Francis
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized
by pervasive difficulties since early childhood across reciprocal social communication and …
by pervasive difficulties since early childhood across reciprocal social communication and …
[HTML][HTML] Autism, oxytocin and interoception
E Quattrocki, K Friston - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
Autism is a pervasive developmental disorder characterized by profound social and verbal
communication deficits, stereotypical motor behaviors, restricted interests, and cognitive …
communication deficits, stereotypical motor behaviors, restricted interests, and cognitive …
Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring
R Tyzio, R Nardou, DC Ferrari, T Tsintsadze… - Science, 2014 - science.org
We report that the oxytocin-mediated neuroprotective γ-aminobutyric acid (GABA) excitatory-
inhibitory shift during delivery is abolished in the valproate and fragile X rodent models of …
inhibitory shift during delivery is abolished in the valproate and fragile X rodent models of …