Endogenous glucocorticoids are crucial to various physiological processes, including
metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have …

Glucocorticoids (GCs) are small lipid hormones produced by the adrenals that maintain
organismal homeostasis. Circadian and stress-induced changes in systemic GC levels …

Empirical and anecdotal evidence has associated stress with accelerated hair greying
(formation of unpigmented hairs),, but so far there has been little scientific validation of this …

Animals receive environmental stimuli from neural signals in order to produce hormones that
control immune responses. Glucocorticoids (GCs) are a group of steroid hormones …

Chronic, sustained exposure to stressors can profoundly affect tissue homeostasis, although
the mechanisms by which these changes occur are largely unknown. Here we report that the …

Mammals evolved in the face of fluctuating food availability. How the immune system adapts
to transient nutritional stress remains poorly understood. Here, we show that memory T cells …

Group 3 innate lymphoid cells (ILC3s) are major regulators of inflammation, infection,
microbiota composition and metabolism. ILC3s and neuronal cells have been shown to …

Chronic stress is associated with increased risk of metastasis and poor survival in cancer
patients, yet the reasons are unclear. We show that chronic stress increases lung metastasis …

Glucocorticoids are steroid hormones with potent immunosuppressive properties. Their
primary source is the adrenals, where they are generated via de novo synthesis from …

Cartilage and bone are severely affected by glucocorticoids (GCs), steroid hormones that
are frequently used to treat inflammatory diseases. Major complications associated with long …