[HTML][HTML] Perspective of immunopathogenesis and immunotherapies for Kawasaki disease

L Chang, HW Yang, TY Lin, KD Yang - Frontiers in Pediatrics, 2021 - frontiersin.org
Kawasaki Disease (KD) is an acute inflammatory illness that mostly occurs in children below
5 years of age, with intractable fever, mucocutaneous lesions, lymphadenopathy, and …

[HTML][HTML] Regulatory T cell-targeted immunomodulatory therapy for long-term clinical improvement of atopic dermatitis: hypotheses and perspectives

DH Nahm - Life, 2023 - mdpi.com
Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disorder characterized by
itching and eczematous lesions. It is often associated with a personal or familial history of …

[HTML][HTML] IgG from Adult Atopic Dermatitis (AD) Patients Induces Nonatopic Neonatal Thymic Gamma–Delta T Cells (γδT) to Acquire IL-22/IL-17 Secretion Profile with …

BO Fagundes, TR de Sousa, A Nascimento… - International Journal of …, 2022 - mdpi.com
γδT cells mature in the human thymus, and mainly produce IL-17A or IFN-γ, but can also
produce IL-22 and modulate a variety of immune responses. Here, we aimed to evaluate …

[HTML][HTML] IgG from adult atopic dermatitis (AD) patients induces thymic IL-22 production and CLA expression on CD4+ T cells: Possible epigenetic implications …

TR de Sousa, BO Fagundes, A Nascimento… - International Journal of …, 2022 - mdpi.com
Atopic dermatitis (AD) is a common relapsing inflammatory skin disorder characterized by
immune-mediated inflammation and epidermal barrier dysfunction. The pathogenesis of AD …

[HTML][HTML] Differential modulation of IL-4, IL-10, IL-17, and IFN-γ production mediated by IgG from Human T-lymphotropic virus-1 (HTLV-1) infected patients on healthy …

NR Machado, BO Fagundes, LA Fernandes… - Frontiers in …, 2023 - frontiersin.org
Human T-lymphotropic virus 1 (HTLV-1) infected individuals remain as asymptomatic
carriers (ACs) or can develop the chronic neurological disorder HTLV-1-associated …

[HTML][HTML] IgG from Dermatophagoides pteronyssinus (Der p)-atopic individuals modulates non-atopic thymic B cell phenotype (alfa-4/beta-7) and cytokine production …

DT de-Apoena Reche, NR Machado, BO Fagundes… - Scientific Reports, 2024 - nature.com
Studies about thymic B cells are scarce in the literature, but it was suggested that they can
exert modulatory and regulatory functions on the immune system. Thymic B cells can play …

IgG from patients with mild or severe COVID‑19 reduces the frequency and modulates the function of peripheral mucosal-associated invariant T cells in PBMCs from …

NR Machado, BO Fagundes… - Biomedical …, 2023 - spandidos-publications.com
Lower levels of peripheral mucosal‑associated invariant T (MAIT) cells have been observed
in the peripheral blood of patients with severe coronavirus disease 2019 (COVID‑19) …

[HTML][HTML] Natural self-ligand gamma delta T cell receptors (γδTCRs) insight: the potential of induced IgG

TR de Sousa, JR Victor - Vaccines, 2020 - mdpi.com
A γδ T cell acquires functional properties in response to the gamma delta T cell receptor
γδTCR signal strength during its development in the thymus. The elucidation of the potential …

[HTML][HTML] Mechanism underlying polyvalent IgG-induced regulatory T cell activation and its clinical application: Anti-idiotypic regulatory T cell theory for immune …

JR Victor, DH Nahm - Frontiers in Immunology, 2023 - frontiersin.org
The regulatory T (Treg) cells constitute a functionally defined subpopulation of T cells that
modulate the immune system and maintain immune tolerance through suppression of the …

[HTML][HTML] The potential of IgG to induce murine and human thymic maturation of IL-10+ B Cells (B10) revealed in a pilot study

AHS Inoue, AAL Lira, MG De-Oliveira, TR de Sousa… - Cells, 2020 - mdpi.com
Regulatory B (B10) cells can control several inflammatory diseases, including allergies;
however, the origin of peripheral B10 cells is not fully understood, and the involvement of …