Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …

Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …

The NADase SARM1 (sterile alpha and TIR motif containing 1) is a key executioner of axon
degeneration and a therapeutic target for several neurodegenerative conditions. We show …

Axonal degeneration is responsible for disease progression and accumulation of disability
in many neurodegenerative conditions. The axonal degenerative process can generate a …

Axonal degeneration is an early and ongoing event that causes disability and disease
progression in many neurodegenerative disorders of the peripheral and central nervous …

Axonal degeneration is a common pathological feature in many acute and chronic
neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif …

Attempts to develop neuroprotective treatments for neurodegenerative disorders have not
yet been clinically successful. Axonal degeneration has been recognized as a predominant …

Axon degeneration is a central pathological feature of many neurodegenerative diseases.
Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is a nicotinamide …

Highlights•A mechanistic understanding of the endogenous axon degeneration pathway has
emerged over the past few years.•Axonal health is maintained by a balance of survival …

SARM1 is the central executioner of pathological axon degeneration, promoting axonal
demise in response to axotomy, traumatic brain injury, and neurotoxic chemotherapeutics …