[HTML][HTML] Mechanisms and management of thyroid disease and atrial fibrillation: Impact of atrial electrical remodeling and cardiac fibrosis

A Takawale, M Aguilar, Y Bouchrit, R Hiram - Cells, 2022 - mdpi.com
Atrial fibrillation (AF) is the most common cardiac arrhythmia associated with increased
cardiovascular morbidity and mortality. The pathophysiology of AF is characterized by …

[HTML][HTML] Gut Microbiota and Atrial Fibrillation: Pathogenesis, Mechanisms and Therapies

AM Al-Kaisey, W Figgett, J Hawson… - Arrhythmia & …, 2023 - ncbi.nlm.nih.gov
Over the past decade there has been an interest in understanding the role of gut microbiota
in the pathogenesis of AF. A number of studies have linked the gut microbiota to the …

Cardiomyocyte and endothelial cells play distinct roles in the tumor necrosis factor (TNF)-dependent atrial responses and increased atrial fibrillation vulnerability …

R Lakin, N Polidovitch, S Yang, M Parikh… - Cardiovascular …, 2023 - academic.oup.com
Aims Endurance exercise is associated with an increased risk of atrial fibrillation (AF). We
previously established that adverse atrial remodeling and AF susceptibility induced by …

Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation

J Song, JA Navarro-Garcia, J Wu… - The Journal of …, 2023 - Am Soc Clin Investig
Chronic kidney disease (CKD) is associated with a higher risk of atrial fibrillation (AF). The
mechanistic link between CKD and AF remains elusive. Interleukin (IL)-1β, a main effector of …

[HTML][HTML] Large unstained cell (LUC) count as a predictor of carotid artery occlusion

TK Urbanowicz, M Rodzki, M Michalak… - Adv Clin Exp …, 2023 - advances.umw.edu.pl
Background. Carotid artery stenosis is often considered a stable clinical condition, and the
underlying atherosclerosis is thought to have an inflammatory background. Objectives. The …

[HTML][HTML] Cytotoxic CD8+ T Cells Are Involved in the Thrombo-Inflammatory Response during First-Diagnosed Atrial Fibrillation

J Friebel, M Witkowski, M Wegner, L Blöbaum… - Cells, 2022 - mdpi.com
Background: Atrial myopathy and atrial fibrillation (AF) accompany thrombo-inflammation.
This facilitates disease progression and promotes major adverse cardiovascular events …

In silico analysis of the dynamic regulation of cardiac electrophysiology by Kv11.1 ion‐channel trafficking

S Meier, A Grundland, D Dobrev… - The Journal of …, 2023 - Wiley Online Library
Cardiac electrophysiology is regulated by continuous trafficking and internalization of ion
channels occurring over minutes to hours. Kv11. 1 (also known as hERG) underlies the …

High‐phosphate diet causes atrial remodeling and increases atrial fibrillation vulnerability via STAT3/NF‐κB signaling and oxidative stress

YJ Hsu, GJ Chang, YJ Lai, YH Chan… - Acta …, 2023 - Wiley Online Library
Aim Hyperphosphatemia is associated with adverse cardiovascular outcomes in both the
general population and patients with end‐stage renal disease. We evaluated whether high …

Diversity of cells and signals in the cardiovascular system

E Grandi, MF Navedo, JJ Saucerman… - The Journal of …, 2023 - Wiley Online Library
This white paper is the outcome of the seventh UC Davis Cardiovascular Research
Symposium on Systems Approach to Understanding Cardiovascular Disease and …

Selective blockade of interleukin 6 trans-signaling depresses atrial fibrillation

X Li, X Wu, X Chen, S Peng, S Chen, G Zhou, Y Wei… - Heart Rhythm, 2023 - Elsevier
Background Atrial fibrillation (AF) has been accepted as an inflammatory atrial myopathy.
Interleukin 6 (IL-6)–dependent inflammatory signaling pathways take context-dependent …