Male infertility is a common and complex problem affecting 1 in 20 men. Despite voluminous
research in this field, in many cases, the underlying causes are unknown. Epigenetic factors …

The human OCT4 gene can generate at least three transcripts (OCT4A, OCT4B, and
OCT4B1) and four protein isoforms (OCT4A, OCT4B-190, OCT4B-265, and OCT4B-164) by …

Induced pluripotent stem cells (iPSCs) are generated from mouse and human fibroblasts by
the introduction of three transcription factors: Oct3/4, Sox2, and Klf4. The proto-oncogene …

OCT4 is a master regulator of self-renewal in embryonic stem cells and can potentially
encode two spliced variants, designated OCT4A and OCT4B. We have examined the …

Long non-coding RNAs (lncRNAs) have been shown to epigenetically regulate certain
genes in human cells. Here we report evidence for the involvement of an antisense lncRNA …

Combined action of SOX and POU families of transcription factors plays major roles in
embryonic development. In embryonic stem cells, the combination of SOX2 and POU5F1 …

Disorders of sex development (DSD), previously referred to as intersex disorders, comprise
a variety of anomalies defined by congenital conditions in which chromosomal, gonadal, or …

Because they are generally noncoding and thus considered nonfunctional and unimportant,
pseudogenes have long been neglected. Recent advances have established that the DNA …

In this study, we show that NANOG, a master transcription factor, regulates S-phase entry in
human embryonic stem cells (hESCs) via transcriptional regulation of cell cycle regulatory …

Completion of early stages of tumorigenesis relies on the dynamic interplay between the
initiating oncogenic event and the cellular context. Here, we review recent findings …