Hereditary channelopathies, that is, mutations in channel genes that alter channel function
and are causal for the pathogenesis of the disease, have been described for several …

Sensory nerves are equipped with receptors and ion channels that allow them to detect and
respond to diverse chemical, mechanical, and thermal stimuli. These sensory proteins …

Activation of the TRPM8 ion channel in sensory nerve endings produces a sensation of
pleasant coolness. Here we show that inflammatory mediators such as bradykinin and …

Astringency is an everyday sensory experience best described as a dry mouthfeel typically
elicited by phenol-rich alimentary products like tea and wine. The neural correlates and …

In the last few years the interactome of Gαq has expanded considerably, contributing to
improve our understanding of the cellular and physiological events controlled by this G …

Cytosolic Ca2+ signals are organized in complex spatial and temporal patterns that underlie
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …

Transient receptor potential melastatin 8 (TRPM8) was originally cloned from prostate tissue.
Shortly thereafter, the protein was identified as a cold-and menthol-activated ion channel in …

Endothelial cell adhesion and migration are critical steps of the angiogenic process, whose
dysfunction is associated with tumor growth and metastasis. The TRPM8 channel has …

Transient receptor potential (TRP) cation channel superfamily plays critical roles in variety of
processes, including temperature perception, pain transduction, vasorelaxation, male …

Camphor is known to potentiate both heat and cold sensations. Although the sensitization to
heat could be explained by the activation of heat-sensitive transient receptor potential (TRP) …